血管紧张素转换酶抑制剂辅助激素治疗原发性肾病综合征的效果

Effect of angiotensin converting inhibitor assist hormone in the treatment of primary nephrotic syndrome

目的探讨血管紧张素转换酶抑制剂辅助激素治疗原发性肾病综合征的效果。方法选取2013年11月~2015年11月在本院接受临床治疗的60例原发性肾病综合征患者作为研究对象,按照随机数字表法分为对照组和实验组,各30例。对照组进行激素治疗,实验组进行血管紧张素转换酶抑制剂辅助激素治疗,比较两组的效果。结果实验组的总有效率为83.33%,显著高于对照组的50.00%,差异有统计学意义(P<0.05)。两组治疗后的24 h尿蛋白、尿素氮、血肌酐水平低于治疗前,血浆白蛋白水平高于治疗前,差异有统计学意义(P<0.05)。实验组治疗后的24 h尿蛋白、尿素氮、血肌酐水平低于对照组治疗后,血浆白蛋白水平高于对照组治疗后,差异有统计学意义(P<0.05)。实验组的不良反应总发生率为3.33%,显著低于对照组的16.67%,差异有统计学意义(P<0.05)。结论血管紧张素转换酶抑制剂辅助激素治疗原发性肾病综合征的效果较好。

Objective To investigate the effect of angiotensin converting inhibitor assist hormone in the treatment of pri- mary nephrotic syndrome.Methods 60 primary nephrotic syndrome patients treated in our hospital from November 2013 to November 2015 were selected as study objects.All patients were divided into the control group and the experimental group according to the random number table method,and each group was 30 cases.The control group was treated with hormone and the experimental group was treated with angiotensin converting inhibitor assist hormone.The treatment ef- fect of the two groups was compared.Results The total effective rate in the experimental group was 83.33%,which was higher than that in control group （50.00%）,with significant difference （P〈0.05）.The level of 24 h urinary protein,urea ni- trogen,serum creatinine after treatment in the two groups was lower than that before treatment,the level of plasma albu- min after treatment in the two groups was higher than that before treatment,with significant difference （P〈0.05）.The lev- el of 24 h urinary protein,urea nitrogen,serum creatinine after treatment in the experimental group was lower than that in the control group after treatment,the level of plasma albumin after treatment in the experimental group was higher than that in the control group after treatment,with significant difference （P〈0.05）.The total incidence rate of adverse re- action in the experimental group was 3.33%,which was lower than that in the control group （16.67%）,with significant difference （P〈0.05）.Conclusion The effect of angiotensin converting enzyme inhibitors in the treatment of primary nephrotie syndrome is better.