桂枝茯苓胶囊辅助治疗围绝经期子宫肌瘤的可行性分析

Feasibility analysis of Guizhi Fuling Capsules in the treatment of perimenopausal uterine fibroids

目的分析桂枝茯苓胶囊辅助治疗围绝经期子宫肌瘤的可行性。方法选择2015年1月~2016年1月在我院进行治疗的围绝经期子宫肌瘤患者387例,根据治疗方法将其分为观察组(200例)和对照组(187例)。对照组患者给予米非司酮片口服,12.5 mg/次,1次/d;观察组在对照组的基础上加用桂枝茯苓胶囊,4粒/次,3次/d,所有患者均连续治疗6个月。比较两组患者的治疗效果;检测并比较两组患者治疗前后雌二醇(E2)、孕激素(P)、黄体生成素(LH)及卵泡刺激素(FSH)等性激素水平和子宫肌瘤体积的变化情况。结果观察组和对照组的总有效率分别为96.00%和75.40%,两组比较差异有统计学意义(P<0.05);治疗后,两组患者血清中E、P、LH、FSH水平均显著低于治疗前,且观察组患者显著低于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者的子宫肌瘤体积显著小于治疗前,且观察组明显小于对照组,差异均有统计学意义(P<0.05)。结论给予围绝经期子宫肌瘤患者米非司酮和桂枝茯苓胶囊进行联合治疗,可以有效提高其疗效,适合临床推广。

Objective To analyze the feasibility of Guizhi Fuling Capsules in the treatment of uterine leiomyoma in perimenopausal period.Methods 387 cases of women with uterine leiomyoma in perimenopausal period treated in our hospital from January 2015 to January 2016 were randomly divided into observation group （200 cases） and control group （187 cases） according to treatment methods.Patients in the control group were treated with oral Mifepristone Tablets, 12.5 mg once,qd;patients in the observation group were given Guizhi Fuling Capsule based on the control group,4 capsules each time,tid,all patients were treated for 6 months.The therapeutic effects were compared between the two groups after treatment;the levels of estradiol （E2）,hormones （P）,luteinizing hormone （LH）,follicle stimulating hormone （FSH） and the volume of uterine leiomyoma were measured and compared before and after treatment.Results The total effective rate of the observation group and the control group was 96.00% and 75.40% ,the difference between the two groups was statistically significant （P〈0.05）.After treatment,the serum levels of E2,P,LH and FSH in the two groups were significantly lower than those before treatment,and the levels of the observation group were significantly lower than those of the control group,the differences were statistically significant （P〈0.05）;the volume of uterine fibroids of the two groups was significantly less than that before treatment,and the volume of uterine leiomyoma in the observation group was significantly less than that in the control group,the differences were statistically significant （P〈0.05）.Conclusion Mifepristone combined with Guizhi Fuling Capsules can effectively improve the curative effect of patients with uterine leiomyoma in perimenopausal period,suitable for clinical promotion.