再发子痫前期危险因素的分析

The Risk Factors of Recurrent Preeclampsia

目的:探讨再发子痫前期(PE)的相关危险因素。方法:采用回顾性病例对照研究的方法,选择2010年1月至2014年12月西安交通大学第一附属医院住院的有2次单胎妊娠且前次妊娠合并PE的孕妇139例为研究对象,根据第2次妊娠是否再次发生PE分为再发PE组(84例)和对照组(55例)。采用单因素分析及二项分类Logistic回归分析各因素和再发PE之间的相互关系。结果:单因素分析显示:再发PE组与对照组中再次妊娠时的年龄、再次妊娠孕前体质量指数(BMI)、前次妊娠PE发病孕周和终止孕周、两次妊娠间隔时间、合并慢性高血压的比较,差异有统计学意义(P<0.05)。二项分类Logistic回归显示:再次妊娠时的年龄(≥35岁)、再次妊娠孕前超重及肥胖(BMI≥24 kg/m^2)、两次妊娠间隔时间(≥5年)是PE再次发生的独立危险因素(P<0.05)。结论:对于有再发PE独立危险因素的妇女,孕期应积极采取有效的预防及监测,避免PE的再次发生。

Objective：The purpose of this study was to investigate the related risk factors of recurrent preeclampisa so that improve the maternal and fetal outcomes. Methods： A retrospective case-control study was conducted using the data from the Obstetrics and Gynecology department in First Affilated Hospital of Xi＇an Jiaotong University from 2010 to 2014. The cohort include patients had second singleton pregnancy with the first pregnancy complicated with preeclampsia,including 84 women with preeclampsia and 55 women without preeclampsia in the subsequent pregnancy. Data was analyzed using univariate analysis and binary logistic regression. Re- sults：Univariate analysis showed that age and pre-pregnancy BMI of the subsequent pregnancy,the gestational time at onset and termination of the previous preeclampsia pregnancy, interval time of pregnancy and complicated with chronic hypertension may have an effect on the recurrence of preeclampsia（ P 〈0.05）. Binary Iogitic regression analysis showed that only age（≥35y） ,pre-pregnancy BMI of the subsequent pregnancy（ ≥24 kg/m^2） and interval time of pregnancy（≥5y） may affect the onset of recurrent preeclampsia（ P 〈 0.05）. Conclusions：We should take effectively prevention and monitoring measures to avoid the recurrence of PE in patients have the risk factors of recurrent preeclampsia.