基于NMR的代谢组学技术在药用植物研究中的应用

The application of NMR-based metabolomics technique to medicinal plants

基于核磁共振的代谢组学技术已普遍应用于植物学方面的研究。植物代谢产物复杂多样,代谢组学的方法能够描述植物整体代谢轮廓、跟踪有价值的代谢产物,为植物生理状态、代谢途径及功能基因等方面研究提供信息。本文主要介绍的是基于NMR的代谢组学技术在药用植物中的应用,包括探究药用植物次级代谢产物合成机制、辅助药用植物的生产、提高药用植物的产量和质量、开发有效活性成分、物种鉴定及中药质量控制等方面的应用,并对今后的发展潜力进行分析。

NMR-based metabolomics technique has been applied to botanical studies in recent years. The plant metabolites are complicated and various, metabolomics method can detect the global metabolomic profile of the plant to track valuable metabolites, and provide information for the research of plant physiology, metabolic pathways and functional genes. This paper reviews the application of NMR-based metabolornics technique in medicinal plants, including the biosynthetic mechanism and production of secondary metabolites, the improve- ment of yield or quality of medicinal plants, the development of effective active ingredient, the identification of medicinal plant species, and the quality control of herbal medicine. In addition, the potential development of this technique in future is discussed.