老年与青壮年HIV/AIDS住院病人临床流行病学的对比分析

Analysis of comparison between the old and young HIV/AIDS inpatients in clinical epidemiology

目的了解广西老年与青壮年艾滋病病毒(HIV)感染者/艾滋病(AIDS)住院病人(简称HIV/AIDS住院病人)临床流行病学的异同,为制定对老年病人有针对性的防治措施提供参考。方法收集近4年某医院住院的HIV/AIDS成年病人的临床流行病学资料,年龄≥50岁者为老年组,余为青壮年组,比较两组之间异同。结果入组病人2 420例,老年组1 123例,占46.4%;青壮年组1 297例,占53.6%。老年组CD4+T淋巴细胞计数中位数为82个/μL,青壮年为37个/μL。除男性比率老年为78.8%与青壮年为78.2%无差异外,老年组农民占73.1%,居住农村占68.4%,已婚占75.2%,初中以下文化占89.7%,异性性传播占94.5%,女性配偶检测阳性率84.4%;青壮年组相对应分别为46.9%、47.0%、56.2%、77.7%、79.3%、41.8%。老年组的不良预后为22.0%,其中非HIV相关疾病不良预后占26.7%,青壮年组分别为17.9%和13.4%,两组以上资料对比的差异有统计学意义(P<0.05)。结论老年病人在该组HIV/AIDS住院病人中的比例高,农村男性为主要人群,绝大多数为异性性传播,CD4+T淋巴细胞计数相对较高,但预后较差,非HIV相关病症多。

Objective To investigate the similarities and differences between the old and young HIV/AIDS inpa- tients in clinical epidemiology,and to provide reference targeted for the old patients in control and prevention. Meth- od Collected the clinical epidemiological data of HIV/AIDS adult inpatients nearly during the past four years. Di- vided those whose ages were over 50 years as old group,and the rest as young group. Compared the similarities and differences between the two groups. Results In the 2420 enrolled cases, the old patients accounted for 46.4%（1123 cases）, the young for 53.6%（1297 cases）. The median of CD4^＋ T lymphocyte count of the old group was 82 ceils/μL, while the young group was 37 cells/μL. There was no significant difference in men proportion between the old group （78.8%） and young group （78.2%）. For the old group, peasants accounted for 73.1%; rural resident ac- counted for 68.4%; patients within marriage accounted for 75.2%; patients with education under junior school graduate accounted for 89.7%; 94.5% patients got infected through heterosexual transmission; 84.4% spouse of female patients were HIV positive. While the rates for young group were accordingly as follows：46.9%, 47.0%, 56.2%, 77.7%, 79.3% and 41, 8%. 22.0% old patients were in poor prognosis; 26.7 % patients had a poor prognosis uncorrelated with HIV infection,while for the young,the rates were accordingly 17.9% and 13.4% ,which was significant in statistical difference （P〈0.05）. Conclusions There was a high ratio of old age among the enrolled HIV/AIDS inpatients. The infected were mainly men from rural areas. CD4^＋ T lymphocyte count but poor progno- sis; and they were complicated with more non-HIV-related diseases.