左卡尼汀联合辅酶Q10治疗重症CHF对心功能、炎症因子水平的影响

Influence of L-carnitine combined with coenzyme Q10 to cardiac function and inflammatory factors in treatment of severe CHF

目的探讨左卡尼汀联合辅酶Q10治疗重症慢性心力衰竭(CHF)对患者心功能、炎症因子水平的影响。方法选取2015年1月~2016年5月在我院进行诊治的的120例重症CHF患者,采用SPSS16.0生成随机数字表法分为治疗组、常规组各60例,两组均给予强心、利尿、扩张血管等基础治疗,治疗组同时加用左卡尼汀联合辅酶Q10治疗。结果治疗后,治疗组患者的LVEF水平高于常规组(P<0.05),治疗组的LVEDd、LVESd、BNP水平低于常规组(P<0.05),治疗组患者的hs-CRP、IL-6、TNF-α水平均低于常规组(P<0.05);治疗组患者的总有效率90.00%高于常规组的76.67%(P<0.05)。结论左卡尼汀联合辅酶Q10治疗重症CHF患者效果显著、安全性高。

Objective To explore the influence of L-carnitine combined with coenzyme Q10 to cardiac function and inflammatory factors in treatment of severe CHF. Methods 120 cases of severe CHF cured in our hospital from January 2015 to May 2016 were selected.They were divided into treatment group and routine group with 60 cases in each according to random numbers generated by SPSS16.0.All the patients in the two groups were given strong heart,diuretic,vasodilator and other basic treatment.Patients in treatment group were combined with Levocarnitine combined with coenzyme Q10 treatment. Results After treatment, the LVEF level in the treatment group was higher than that in the conventional group （P 〈 0.05）.The levels of LVEDd,LVESd and BNP in the treatment group were lower than those in the conventional group （P 〈 0.05）.The hs-CRP, IL-6 and TNF-alpha in treatment group were lower than those in normal group （P 〈 0.05）.The total effective rate of the treatment group was 90% higher than that of the conventional group （P 〈 0.05）. Conclusion L-carnitine combined with coenzyme Q10 in treatment of severe CHF has significant effect and high safety.