ST2与冠心病的研究进展

Research progress of ST2 and coronary heart disease

ST2,即生长刺激基因表达蛋白2,是一种新型心肌蛋白,它以可溶性的ST2(s ST2)和与细胞膜结合的ST2(ST2L)两种形式存在。在机械应力诱导下由心肌细胞产生,心肌细胞产生的大量s ST2与IL-33结合,从而竞争性抑制ST2L与IL-33的结合,阻断了ST2L的信号传导通路,降低来自于IL-33/ST2L信号通路的心肌保护作用,从而导致心肌肥大及心肌纤维化。有研究表明,血清ST2水平可高表达于急性心肌梗死患者,且能评估心功能不全患者的预后情况。本文主要就ST2与冠心病关系的研究进展作一综述。

ST2,namely the growth stimulating protein 2 gene expression, is a new kind of cardiac muscle protein. It exists in two forms, those were soluble ST2 （sST2） and ST2 （ST2L） who combine with the membrane. Under mechanical Stress, it is produced by myocardial cells. Large amounts of sST2 produced by myocardial cells were combined with IL-33, which Competitively inhibitis the binding of ST2L to IL-33. It blocks the ST2L signaling pathways, and decreases from IL-33 / ST2L signal pathway of myocardial protection, which leads to myocardial hypertrophy and myocardial fibrosis. Some studies have shown that serum ST2 level can be high expression in patients with acute myocardial infarction, and can assess the prognosis in patients with cardiac insufficiency. This article reviews the research progress of the relationship between ST2 and coronary heart disease