氟西汀联合阿司匹林肠溶片、阿托伐他汀片治疗老年急性冠脉综合征患者抑郁的效果观察

Effect of fluoxetine combined with aspirin enteric-coated tablets and atorvastatin on depression in elderly patients with acute coronary syndrome

目的探讨氟西汀联合阿司匹林肠溶片、阿托伐他汀片治疗老年急性冠脉综合征(ACS)患者抑郁的临床效果。方法将本院2014年1月~2015年11月期间收治的100例ACS患者作为研究对象,随机分成对照组和观察组组,每组各50例,对照组患者给予口服阿司匹林肠溶片、阿托伐他汀片等常规治疗,观察组在对照组基础上加服氟西汀,比较两组的治疗效果。结果与治疗前比较,两组血清TC、TG、LDL-C和hs-CRP均明显下降(P<0.05),而观察组下降幅度更大,与对照组比较差异有统计学意义(P<0.05);两组治疗前后血清HDL-C水平无明显变化(P>0.05);两组患者治疗前HAMD评分比较差异无统计学意义(P>0.05);治疗后,观察组HAMD评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为14.0%,对照组不良反应发生率为10.0%,两组不良反应发生率比较差异无统计学意义(χ2=0.095,P=0.758)。结论氟西汀联合阿司匹林肠溶片、阿托伐他汀片治疗老年急性冠脉综合征(ACS)患者抑郁的临床效果显著,可在临床推广。

Objective To investigate the clinical effect of fluoxetine combined with aspirin enteric-coated tablets and atorvastatin in the treatment of senile acute coronary syndrome （ACS）. Methods 100 patients with ACS were enrolled in this study from January 2014 to November 2015. They were randomly divided into control group and observation group with 50 cases in each. Patients in control groups were treated with oral aspirin enteric-coated tablets, atorvastatin tablets and other conventional treatment, and patients in observation group were plus fluoxetine on the basis of the control group. The two groups of treatment of the two groups were compred. Results Compared with before the treatment, the levels of TC, TG, LDL-C and hs-CRP in the two groups were significantly decreased （P 〈 0.05）, and the decreases degree of ovservation group was bigger than that of control group, and the difference was statistically significant （P 〈 0.05）. There was no significant difference in serum HDL-C level between the two groups before and after treatment （P 〉 0.05）. The HAMD scores of the two groups were not statistically significant （P 〉 0.05）. After treatment, the HAMD score of the observation group was lower than that of the control group; the difference was statistically significant （P 〈 0.05）. The incidence of adverse reactions in the observation group was 14.0%, and the incidence of adverse reactions in the control group was 10.0%. There was no significant difference in the incidence of adverse reactions between the two groups 0y2=0.095, P=0.758）. Conclusion The clinical effect of fluoxetine combined with aspirin enteric-coated tablets and atorvastatin tablets in the treatment of senile acute coronary syndrome （ACS） is significant, and it can be popularized in clinical practice.