氟哌噻吨治疗男性无自知力精神分裂症伴高泌乳素血症疗效研究

Efficacy of Flupentixol in Treating Male Schizophrenia with No Insight and Highprolactinemia

目的探讨氟哌噻吨治疗男性无自知力精神分裂症伴高泌乳素血症的疗效。方法选择医院2015年8月至2016年8月收治的81例无自知力精神分裂症伴高泌乳素血症男性患者,分为对照组40例(予以利培酮口服)和研究组41例(在对照组基础上予以氟哌噻吨),总疗程均为8周。对比两组患者的治疗效果。结果治疗后,对照组中能自主服药12例,护理者帮助服药17例,不愿服药11例;研究组中能自主服药29例,护理者帮助服药8例,不愿服药4例;研究组服药自主性明显优于对照组(P<0.05)。治疗前,两组自知力记忆治疗态度调查问卷(ITAQ)评分无明显差异(P>0.05);治疗4,8周时,研究组的评分均高于对照组(P<0.05);治疗4周时,两组患者较入院时评分显著提高(P<0.05);治疗8周时,两组患者评分均比第4周明显增高(P<0.05)。对照组患者治疗前后血泌乳素水平变化不明显(P>0.05),研究组患者治疗后血泌乳素水平明显低于治疗前(P<0.05);治疗前,两组患者的血泌乳素水平无显著差异(P>0.05),治疗后,研究组患者的血泌乳素水平明显低于对照组患者(P<0.05)。治疗前,两组患者阴性和阳性症状评定表(PANSS)评分比较无明显差异(P>0.05);治疗后,研究组患者评分明显低于对照组患者(P<0.05)。结论氟哌噻吨对男性无自知力精神分裂症伴高泌乳素血症有良好的治疗作用,值得临床推广。

Objective To investigate the therapeutic effect of Flupentixol on schizophrenia with no insight and hyperprolactinemia in male. Methods 81 schizophrenia patients with no insight from August 2015 to August 2016 in the hospital were enrolled in this study. 40 patients in the control group were treated with Risperidone orally. On the basis, 41 patients in the study group were added with Flupentixol orally. The total course of treatment was 8 weeks. The therapeutic effect of the two groups were compared. Results After treatment, there were 12 cases in the control group that could self-medication, 17 cases that could take medicine under the help of the caregivers, 11 cases that still did not want to take medicine; while in the study group, the numbers were 29 cases, 8 cases, 4 cases, which showed that the study group tended to have a better degree in spontaneous medication（ P 〈 0. 05）. There was no significant dif- ference in ITAQ scores between the two groups before treatment（P 〉 0.05）. At 4, 8 weeks of treatment, the score of the study group were higher than those of the control group（P 〈 0. 05）. At the 4 weeks of treatment, the scores were significantly higher in the two groups than admitted to the hospital（P 〈 0. 05）. At 8 weeks of treatment, the scores were significantly higher in the two groups than at 4 weeks（ P 〈 0. 05）. There was no significant change in the level of serum prolactin in the control group before and after treatment （P 〉 0.05）; the level of serum prolactin in the study group was significantly lower than that before treatment（P 〈 0. 05）. There was no significant difference in the level of serum prolactin between the two groups（ P 〉 0. 05）. After treatment, the levels of serum prolactin in the study group were significantly lower than those in the control group（ P 〈 0.05）. There was no significant difference in the clinical score between tile two groups before treatment（ P 〉 0.05）. After treatment, the clinical score of the study group was significantly lower than that of the control group（ P 〈 0. 05）. Conclusion Flupentixol has a good therapeutic effect on the male schizophrenia with no insight and hyperprolactinemia, which is worthy of clinical promotion.