独活寄生汤治疗风湿性关节炎疗效观察

Efficacy of Duhuo Jisheng Decoction in Treating Rheumatoid Arthritis

目的探讨独活寄生汤治疗风湿性关节炎的临床疗效。方法选取2016年1月至9月医院收治的风湿性关节炎患者80例,按随机数字表法分为对照组和观察组,每组40例,分别给予布洛芬和独活寄生汤。比较两组患者的临床疗效,治疗前后晨僵、握力、关节疼痛、20 m步行时间,以及治疗期间的不良反应发生情况。结果与对照组相比,观察组的总有效率明显增高(95.00%vs 75.00%,χ~2=6.27,P<0.05);观察组患者治疗后晨僵时间[(10.21±1.32)min vs 19.81±2.22)min,t=5.24,P<0.05],关节疼痛个数[(1.01±0.22)个vs(3.41±0.52)个,t=4.28,P<0.05],20 m步行时间[(10.21±1.52)s vs(16.21±2.42)s,t=4.59,P<0.05]均明显减少,而握力显著增高[(75.61±3.42)mmHg vs(40.51±2.82)mmHg,t=7.13,P<0.05];治疗期间均未出现严重不良反应。结论独活寄生汤能明显改善风湿性关节炎患者的临床症状,临床疗效及安全性均较高,值得临床推广。

Objective To study the clinical efficacy of Duhuo Jisheng Decoction for rheumatoid arthritis. Methods 80 patients with rheumatoid arthritis in the hospital from January 2016 to September 2016 were randomly divided into the control group（ Ibuprofen） and the observation group（ Duhuo Jisheng Decoction）,40 case in each group. The clinical efficacy,the improvements of morning stiffness,grip strength,joint pain,20 m walking time on pre-and post-treatment,and the adverse reactions in the two groups were compared. Results Compared with the control group,the total effective rate was significantly increased with statistical difference（ 95. 00% vs 75. 00%, χ~2=6. 27, P 〈0. 05）; the morning stiffness time [（ 10. 21 ± 1. 32） min vs（ 19. 81 ± 2. 22） min, t = 5. 24, P 〈0. 05 ],the number of joint pain（ 1. 01 ± 0. 22 vs 3. 41 ± 0. 52, t = 4. 28, P 〈0. 05）,20 m walking time [（ 10. 21 ± 1. 52） s vs（ 16. 21 ± 2. 42） s, t = 4. 59, P〈 0. 05 ] on post-treatment were obviously decreased and the grip strength was significantly increased[（75. 61 ± 3. 42） mmHg vs（40. 51 ± 2. 82） mmHg,t = 7. 13, P〈 0. 05 ] with statistical difference in the observation group; there were no severe adverse reactions during the treatment period in two groups. Conclusion Duhuo Jisheng Decoction can significantly improve the clinical symptoms of patients with rheumatoid arthritis with higher efficacy and safety,which is worthy of clinical promotion.