60例中药注射剂不良反应发生特点与一般规律分析

Occurrence Characteristics and General Rules of Adverse Reactions Induced by Traditional Chinese Medicine Injection in 60 Cases

目的探讨中药注射剂不良反应的发生特点与一般规律。方法选取医院2014年10月至2016年10月收治的60例中药注射剂致不良反应病例,回顾性分析其临床资料,分析药物类型、不良反应类型、患者年龄分布、不良反应发生时间,以及其发生特点与一般规律。结果参麦注射液(25.00%)和血栓通注射液(26.67%)占比均较高(P<0.05),过敏反应(60.00%)占比最高(P<0.05);60岁及以上患者占(51.67%)最多(P<0.05);用药后11~30 min(41.67%)发生不良反应最多(P<0.05)。结论中药注射剂不良反应具有一定的特征性和规律性,掌握其发生特点与一般规律,可提高不良反应风险控制力度,保证临床用药安全。

Objective To investigate the characteristics and general rules of adverse reactions induced by traditional Chinese medicine injections. Methods 60 cases of adverse drug reactions（ ADR） induced by traditional Chinese medicine injections in the hospital from October 2014 to October 2016 were selected as the research objects. The clinical data of patients were collected, and the drug types, adverse reaction types, age distribution of patients, adverse reaction time and its characteristics and general rules were retrospectively analyzed. Results The ADR types of drugs involved Shenmai Injection（25. 00%） and Xueshuantong Injection（ 26. 67%）being the higher two（P〈 0. 05）,the allergic reaction（60. 00%） accounted for the highest（P 〈0. 05）,the age group of more than 60 years old（51. 67%） accounted for the highest（P〈 0. 05）. The incidence time of adverse drug reactions after treatment indicated that 11-30 min（ 41. 67%） accounted for the highest proportion（ P〈 0. 05）. Conclusion ADR induced by traditional Chinese medicine injection has a certain characteristics and regularity. If we master its characteristics and general rules, we can improve the control of the risk of adverse reactions to ensure the safety of clinical medication.