竞争性内源RNA在原发性肝癌中的研究进展

Research progress of the competing endogenous RNA in primary hepatocellular carcinoma

竞争性内源RNA（ceRNA）转录本可通过与微小RNA（miRNA）竞争性结合相同的miRNA应答元件（MRE），从而解除或减轻miRNA对靶基因的抑制作用。近期研究表明，许多基因可作为ceRNA，通过竞争性结合相同的致瘤性或抑瘤性基因，在肝癌发生发展中起促进或抑制肿瘤生成的作用。

Competing endogenous RNAs （ceRNAs） transcripts can communicate with microRNAs （miRNAs） through competitively binding the common miRNA response elements （MREs）, which remove or decrease the repression of target genes of miRNAs. The present studies indicate that a large amount of genes, serving as ceRNAs, can promote or inhibit the occurrence of liver cancer by competing the binding site of same genes that can promote or suppress tumorigenesis.