天然酮类化合物生物活性的研究进展

Review on Pharmacological Activities of Natural Xanthone

天然酮类化合物是一类具有三环芳烃系统(C_6-C_3-C_6)结构的次生代谢产物的总称,该类成分广泛存在于龙胆科、藤黄科、远志科、桑科等植物中,目前研究表明,天然酮类化学成分具有广泛的药理活性,包括抗肿瘤、抗菌、抗病毒、保肝、降血糖、抑制黄嘌呤氧化酶等多种药理作用,有良好的开发前景。本文对近十年来国内外关于酮类化学成分在生物活性及相关作用机制、构效关系等方面的研究进展进行总结,为进一步深入研究和合理开发应用天然酮类药物资源提供理论参考。

Xanthone is a collective name for one kind of natural plant secondary metabolites which possess trieyelic aro- matic structure and widely distributed in the plants of several family such as Gentianaceae, Guttiferae, Polygalaeeae, Moraeeae and Leguminosae. The present studies showed that natural xanthones have wide range of pharmacological activ- ities,including anti-tumor, anti-bacterial, anti-viral, hepatoprotective, pypoglycemie, inhibition of xanthine oxidase, etc. The review on pharmacological activities and related molecular mechanisms, structure-activity relationships of titled con- stituents over the last decade were summarized in this article, by which the prospect of development and utilization of natural xanthones can be prospected. The article provided the reference for the further research and comprehensive utili- zation of the natural xanthone resources.