儿童泛发性脓疱型银屑病9例回顾分析

A Retrospective Analysis of 9 Patients with Generalizedpustular Psoriasis in Childhood

目的探讨儿童泛发性脓疱型银屑病(GPP)的临床特点及治疗。方法按有无伴随寻常性银屑病病史分组,回顾性分析2012年1月-2015年12月本科住院部确诊为GPP的9例患儿共19次住院及随访资料。结果不伴寻常性银屑病GPP患儿(GPP^(pso-))6例,平均发病次数为(2.67±0.42)次,平均发病年龄为(3.57±0.56)岁;伴寻常性银屑病GPP患儿(GPP^(pso+))3例,患儿发病次数均为1次,平均发病年龄为(6.5±1.8)岁;GPPpso-组与GPP^(pso+)组患儿发病时临床表现、治疗方案选择的差异没有统计学意义。结论 GPP^(pso-)患儿容易病情反复,病情控制后缓解期较短,维持阶段患儿系统抗银屑病药物减量应该更为缓慢。

Objective To investigate the clinical feature and therapeutic regime of generalized pustular psoriasis（GPP）in childhood.Methods A retrospective analysis was performed on 9 patients who were diagnosed with GPP in childhood from January 2012 to December 2015. They were grouped by whether had the history with psoriasis vulgaris（PV）.Data from 19 times of hospitalization and follow-up of these patients were analysed.Results There were 6 patients without a history of PV（GPPpso-group）.The average hospitalization number in GPPpso-group were（2.670.42）times. The average age of onset in GPPpso-group were（3.570.56）years. There were 3 patients had a history of PV（GPPpso＋ group）. All children in GPPpso＋ group only hospitalized 1 time. The average age of onset in GPPpso＋ group were（6.51.8）years. There was no significant difference of the clinical features and therapeutic regime between the two groups. Conclusion The children with GPPpso- easy recurred and had shorter remission after disease controlled,and the system antipsoriatic drugs used in this group should be tapered slower in the maintenance stage.