期刊文献+

食管癌的主要发病因素及其机制 被引量:25

Inducing factors of esophagus cancer and the underlying mechanisms
下载PDF
导出
摘要 食管癌是消化系统中最常见的恶性肿瘤之一,具有高发病率,高侵袭性以及预后差等特点。过去大量的研究发现多重因素增加了食管癌的发病风险。这些因素主要包括吸烟酗酒、不合理的饮食、巴雷斯特食管症和基因突变等。本文将对这些因素是诱导食管癌发生的机制进行深入的探讨。 Esophagus cancer is a common malignent tumor in digestive system, with characteristics of high incident, high invasive capacity and poor prognosis. Numerous researches find that tumorigenesis of esophagus cancer is the results of various factors, including smoking, alcohol abuse, unheahh diet, Barrett's esophagus disease and gene muta- tion. This review discusses mechanisms by which these factors induce the tumorigenesis in detail.
出处 《中国医药导报》 CAS 2017年第7期40-44,共5页 China Medical Herald
基金 湖南省卫生计生委科研计划项目(B2015-108)
关键词 食管癌 吸烟酗酒 不合理的饮食 巴雷斯特食管症 基因突变 Smoking Alcohol abuse Unheahh diet Barrett's esophagus disease Gene mutation
  • 相关文献

参考文献2

二级参考文献114

  • 1[1]Gustafsson BE.The physiological importance of the colonic microflora.Scand J Gastroenterol Suppl1982; 77:117-131
  • 2[2]Cunningham-Rundles S,Ahrn S,Abuav-Nussbaum R,Dnistrian A.Development of immunocompetence:role of micronutrients and microorganisms.Nutr Rev 2002; 60:S68-72
  • 3[3]Peek RM Jr,Blaser MJ.Helicobacter pylori and gastrointestinal tract adenocarcinomas.Nat Rev Cancer 2002; 2:28-37
  • 4[4]Gerding DN,Gebhard RL,Su mner HW,Peterson LR.Pathology and diagnosis of Clostridium difficile disease.In:Rolfe R,Finegold SM (eds) Clostridium difficile:its role in intestinal disease.San Diego,Academic Press 1988:259-286
  • 5[5]Hopkins MJ,Macfarlane GT.Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection.J Med Microbiol 2002; 51:448-454
  • 6[6]Hill LV,Embil JA.Vaginitis:current microbiologic and clinical concepts.CMAJ 1986; 134:321-331
  • 7[7]Roediger WE,Lawson MJ,Radcliffe BC.Nitrite from inflammatory cells--a cancer risk factor in ulcerative colitis? Dis Colon Rectum 1990; 33:1034-1036
  • 8[8]Mueller RL,Hagel HJ,Greim G,Ruppin H,Domschke W.Endogenous synthesis of carcinogenic N-nitroso compounds:bacterial flora and nitrite formation in the healthy human stomach.Zentralbl Bakteriol Mikrobiol Hyg[B] 1983; 178:297-315
  • 9[9]Mowat C,Williams C,Gillen D,Hossack M,Gilmour D,Carswell A,Wirz A,Preston T,McColl KE.Omeprazole,Helicobacter pylori status,and alterations in the intragastric milieu facilitating bacterial N-nitrosation.Gastroenterology2000; 119:339-347
  • 10[10]Calmels S,Ohshima H,Henry Y,Bartsch H.Characterization of bacterial cytochrome cd(1)-nitrite reductase as one enzyme responsible for catalysis of nitrosation of secondary amines.Carcinogenesis 1996; 17:533-536

共引文献19

同被引文献300

引证文献25

二级引证文献114

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部