血清总前列腺特异性抗原检测在慢性前列腺炎诊断中的应用价值

Application effect of serum TPSA detection in diagnosis of chronic prostatitis

目的探究血清总前列腺特异性抗原(TPSA)检测在慢性前列腺炎诊断中的应用价值。方法回顾性分析2015年9月~2016年9月在中国医科大学附属第一医院鞍山医院(以下简称"我院")检查并诊断的420例慢性前列腺炎患者的临床资料,根据病理类型的不同将其分为Ⅱ型组(95例)、Ⅲa型组(70例)、Ⅲb型组(100例)、前列腺增生组(95例)以及Ⅳ型组(60例),所有患者均给予对症处理,并取得明显的疗效。另取同期我院健康体检者80例作为对照组。对比分析各组血清TPSA水平,观察各组慢性前列腺炎患者治疗前后血清TPSA水平的变化。结果治疗前,各组血清TPSA水平均明显高于对照组(P<0.01),且前列腺增生组显著高于Ⅳ型组(P<0.01)。治疗后各组患者的血清TPSA水平均较治疗前降低,差异有统计学意义(P<0.05)。治疗前,Ⅱ型组、Ⅲa型组、Ⅲb型组、Ⅳ型组及前列腺增生组患者的TPSA阳性率均高于对照组,且前列腺增生组明显高于Ⅳ型组,差异有统计学意义(P<0.01)。结论血清TPSA检测对于慢性前列腺炎患者的临床分型具有重要的意义,值得推广应用。

Objective To explore the application value of serum TPSA detection in the diagnosis of chronic prostatitis. Methods Clinical data of 420 patients with chronic prostatitis in the First Hospital of China Medical University （for short ＂our hospital＂） from September 2015 to September 2016 were retrospectively analyzed. According to different pathological types, they were divided into the five groups： type Ⅱ group （95 cases）, type Ⅲa group （70 cases）, type ]Ⅱb group （100 cases）, prostate hyperplasia group （95 cases） and type Ⅳ group （60 cases）, respectively, all patients were given the symptomatic treatment, and obtained obvious effect. 80 healthy persons for physical examination in our hospital were taken as the control group at the same period. The level of serum TPSA in the five groups were compared and analyzed. Results Compared with healthy people, chronic prostatitis, level of serum TPSA of patients in the five groups was significantly higher than the control group before treatment （P 〈 0.01）. After treatment, levels of serum TP- SA of patients in each group were reduced, compared with before treatment （P 〈 0.05）. Before treatment, the positive rate of serum TPSA in patients of the type Ⅱ group, type Ⅲa group, type Ⅲb group, type Ⅳ group and prostatic hyperplasia group was higher than that of the control group, and prostatic hyperplasia group was significantly higher than that of the type IV group, the difference was statistically significant （P 〈 0.01）. Conclusion For the treatment of chronic prostatitis patients with serum TPSA detection of clinical specificity, the effect is good, it is worth promoting.