认识女性生殖道癌肉瘤

Knowing carcinosarcoma of the female genital tract

女性生殖道癌肉瘤是一类很少见、侵袭性强、易于复发转移、预后差的肿瘤。该类肿瘤包含癌和肉瘤两种恶性组织成分,目前的研究对此类肿瘤的起源更倾向于转化学说,即认为该类癌瘤为单克隆起源,其中肉瘤成分由癌细胞化生为肉瘤样成分。在治疗上,对癌肉瘤首选手术治疗,术后通常需采用辅助化疗和放疗等综合治疗。

Carcinosarcoma of the female genital tract is a rare but highly aggressive, easily recurrent malignancy with poor prognosis. Pathologically, carcinosarcoma is a biphasic neoplasm composed of a mixture of malignant epithelial and mesenchymal components. Studies have indicated that most carcinosarcomas are essentially high- grade carcinomas with sarcomatous differentiation, which derive from a monoelonal neoplasm.A comprehensive approach to management is recommended with complete surgery, followed by multimodal therapy with combinations of external beam irradiation and/or systematic chemotherapy in patients with both early and advanced stage disease.