小分子化合物诱导胚胎干细胞分化为角膜上皮样细胞的研究进展

The research advance of small molecules inducing embryonic stem cells to differentiate into corneal epithelial-like cells

干细胞因有强大的自我更新能力和多向分化潜能,成为近年来基础医学和临床研究的热点.利用小分子化合物调节效应迅速可逆的特点,从小分子化合物促进胚胎干细胞存活、自我更新及分化发育等方面入手,深入了解小分子化合物对胚胎干细胞的诱导作用,以此探讨在体外将胚胎干细胞诱导分化为角膜上皮样细胞的方法,为角膜细胞移植治疗获得无限制角膜上皮来源,减少临床对受限于角膜供体的角膜移植手术的需求,使更多患者获得有效和及时治疗提供参考途径.

Stem cells are becoming a hot topic of basic medicine and clinical research because of their wide self-renewal and differentiation potential in recent years.A number of small molecules that can be used to control stem cell self-renewal,lineage differentiation,reprogramming and regeneration could regulate stem cell fate quickly and reversibly.If small molecules could induce human embryonic stem cells to differentiate into corneal epithelial-like cells in vivo,corneal cell transplantation therapy will have unlimited source of corneal epithelium.More patients will obtain effective and timely treatment.