分子分型在乳腺癌放疗中的价值及应用

Application of Molecular Subtype in Radiotherapy of Breast Cancer

乳腺癌作为高度分子异质性疾病,根据雌、孕激素受体及Her-2的表达可分为4型。研究显示不同的分型具有明显不同的临床特征,根据分子分型指导患者接受化疗、内分泌治疗或靶向治疗。随着对其研究的深入,越来越多的报道显示分子分型可以指导乳腺癌的放疗。

As a highly heterogeneous disease,according to the progesterone receptor （PR）,estrogen receptor （ER） and the expression of Her-2, breast cancer can be classified into four types. Numerous researches show that different types have its distinct clinical features ,and molecular classification may provide guidance for precise treatment in chemotherapy,endocrine therapy or targeted therapy. Recent studies show that the molecular typing of breast cancer can also be applied into radiotherapy. This article will review the latest advances in this domain.