补脾益肾汤联合三磷酸腺苷+谷维素治疗脾肾阳虚慢性疲劳综合症随机平行对照研究

Randomized Parallel Controlled Study of Bupi Yishen Decoction Combined with Adenosine Triphosphate+ Oryzanol in the Treatment of Chronic Fatigue Syndrome of Spleen-Kidney Yang Deficiency

[目的]观察补脾益肾汤联合三磷酸腺苷+谷维素治疗脾肾阳虚慢性疲劳综合征疗效。[方法]使用随机平行对照方法,将140例门诊患者按就诊先后顺序简单随机分为两组。对照组70例三磷酸腺苷,60mg/次,3次/d;谷维素,20mg/次,3次/d。治疗组70例脾益肾汤(红参10g,白术炒30g,红景天15g,云苓12g,菟丝子15g,补骨脂20g,陈皮12g,山萸肉、山药各15g,清半夏、甘草炙、柴胡各10g;湿盛加石菖蒲、苍术;阳虚明显加干姜、肉桂;失眠加枣仁炒、远志;抑郁加合欢花、佛手);1剂/d,水煎400m L,早晚饭前温服;西药治疗同对照组。连续治疗10d为1疗程。观测临床症状、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组痊愈12例,显效23例,有效24例,无效11例,总有效率84.29%;对照组痊愈12例,显效15例,有效16例,无效27例,总有效率61.53%;治疗组疗效优于对照组(P<0.05)。[结论]补脾益肾汤联合三磷酸腺苷+谷维素治疗脾肾阳虚慢性征劳综合症,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the therapeutic effect of Bupi Yishen decoction combined with adenosine triphosphate＋oryzanol on chronic fatigue syndrome of spleen and kidney yang deficiency. [Methods] One hundred and forty outpatients were randomly divided into two groups according to the order of treatment. Control group, 70 cases of adenosine triphosphate, 60 mg/times, 3 times/d; oryzanol, 20 mg/times, 3 times/d. The treatment group of 70 cases of spleen and kidney soup（red ginseng 10 g, Atractylodes fried 30 g, Rhodiola 15 g, Yunling 12 g, dodder 15 g, psoralen 20 g, dried tangerine peel 12 g, cornus, yam 15 g, clear Pinellia, licorice Sunburn, Bupleurum the 10g; wet Shengjia Shichangpu, atractylodes; Yang star plus ginger, cinnamon; insomnia plus Zaoren fried, Polygala; depression plus Albizia julibrissin, bergamot）; 1/d, decoction 400 m L, warm clothes before dinner; western medicine treatment with the control group. Continuous treatment for 10 d for a course of treatment. Observation of clinical symptoms, adverse reactions. Continuous treatment of 3 courses, determine the efficacy. [Results] In the treatment group, 12 cases were cured, 23 markedly effective, 24 effective, 11 ineffective, the total effective rate was 84.29%; the control group was cured in 12 cases, markedly effective in 15 cases, effective in 16 cases, ineffective in 27 cases, the total effective rate was 61.53%; The curative effect of the treatment group was better than that of the control group（P〈0.05）. [Conclusion] Bupi Yishen decoction combined with adenosine triphosphate＋oryzanol treatment of chronic syndromes of spleen and kidney yang deficiency syndrome, with satisfactory results, no serious adverse reactions, should be promoted.