老年胃食管反流病与慢性咳嗽的相关性

Correlation research of GERD with chronic cough in elderly patients

目的:探讨老年胃食管反流病(gastroesophageal reflux disease,GERD)与慢性咳嗽的关系,为临床治疗提供依据。方法:选取2012年6月至2014年6月收治的86例老年胃食管反流性咳嗽(gastroesophageal reflux cough,GERC)患者作为GERC组,另选取同期行健康体检的健康老年人86例作为对照组。另将GERC组86例患者随机分为A、B两组,各43例,其中口服雷尼替丁联合多潘立酮进行治疗者作为A组,口服奥美拉唑联合莫沙必利进行治疗者作为B组。对所有研究对象进行24 h食管pH检测,以Demeester评分为标准,观察并比较各组研究对象的反流指标。结果:GERC组患者24 h食管pH检测中,反流次数、反流时间等各项反流指标均高于对照组(P<0.05);与治疗前相比,A、B两组患者治疗后各项反流指标均有所改善(P<0.05),治疗后B组患者各项反流指标均优于A组(P<0.05)。结论:老年胃食管反流病与慢性咳嗽有密切关系,对GERC患者采用奥美拉唑联合莫沙必利进行治疗,效果理想,值得临床应用及推广。

Objective ：To study the correlation between gastroesophageal reflux disease （GERD） and chronic cough in elderly patients and pro- vide the reliable basis for clinical treatment. Method： 86 eases of elderly patients with GERC treated from June 2012 to June 2014 were selected as study group; 86 healthy cheek - ups were selected as control group. The study group was randomly divided into group A and group B, 43 cases in each group. The patients in group A orally took Ranitidine eombined with Domperidone and those in group B orally took Omeprazole combined with Mosapride. 24 - hour esophageal PH changes of all study objects were observed and reflux index were compared between the two groups by De- meester standardization. Results： Based on 24 - hour esophageal PH monitoring, the indexes of reflux frequency and time in study group were sig- nificantly larger than those in control group （ P 〈 0.05 ） ; After treatment, Demeester scores in group A and group B improved （ P 〈 0.05 ）. De- meester seore in group B was significantly better than that in group A （ P 〈0.05 ）. Conclusion： GERD is closely correlated with chronic eough in elderly patients. For GERC patients, Omeprazole combined with Mosapride is effective, which is worthy of clinical application and promotion.