胺碘酮与利多卡因治疗急性心肌梗死并室性心律失常的治疗效果

Therapeutic effect of amiodarone and lidocaine on patients with acute myocardial infarction complicated with ventricular arrhythmia

目的:分析胺碘酮与利多卡因治疗急性心肌梗死并室性心律失常的临床治疗效果。方法:急性心肌梗死并室性心律失常患者98例,随机分为观察组和对照组,各49例。观察组患者给予胺碘酮治疗,对照组则给予利多卡因治疗,比较两组患者的临床疗效、心率恢复时间、胸痛症状消失时间、治疗前后24 h动态心电图期前收缩次数及不良反应发生情况。结果:观察组患者的临床治疗总有效率(93.88%)高于对照组(81.63%)(P<0.05)。观察组患者的心率恢复时间和胸痛症状消失时间均短于对照组,治疗后24 h动态心电图期前收缩次数低于对照组,不良反应发生率也低于对照组,差异均具有统计学意义(P<0.05)。结论:胺碘酮治疗急性心肌梗死并室性心律失常的临床效果较利多卡因好,可减少临床症状消失时间,不良反应少,值得推广应用。

Objective ：To analyze the clinical effect of amiodarone and lidocaine in the treatment of acute myocardial infarction complicated with ventricular arrhythmia. Methods：98 patients with acute myocardial infarction complicated with ventricular arrhythmia were randomly divided into experimental group and control group, 49 cases in each group. Patients in the experimental group were treated with amiodarone and the control group received lidocaine. The clinical curative effect, the recovery time of heart rate, the disappearance time of symptom of chest pain, the number of contraction of dynamic electrocardiogram （ECG） 24 h before and after treatment and the occurrence of adverse reactions were compared between the two groups. Results：The total effective rate （93.88 % ） of the experimental group was higher than that in the control group （81.63 % ）, （ P 〈0.05 ）. The recovery time of heart rate and the disappearance time of symptoms of chest pain in the experimental group were shorter than those in the control group（ P 〈0.05 ）. The number of contraction of dynamic ECG was lower than that of the control group at 24 h after treatment（ P 〈 0.05 ）. The incidence of adverse reactions was also lower than that of the control group, the differences statistically significant （ P 〈 0.05 ）. Con- clusion：Amiodarone has better clinical effect than lidocaine in treating acute myocardial infarction complicated with ventricular arrhythmia. It can reduce the time of disappearance of clinical symptoms with less adverse reactions, which is worthy of popularization and application.