无创辅助通气联合肺表面活性物质治疗新生儿急性肺损伤的效果

The effect of noninvasive ventilation combined with pulmonary surfactant in the treatment of neonatal acute lung injury

目的:探讨无创辅助通气联合肺表面活性物质治疗新生儿急性肺损伤的临床效果。方法:自2014年1月至2016年12月间收治的新生儿急性肺损伤患儿120例作为研究对象,随机分为观察组和对照组各60例,对照组患儿采用无创辅助通气治疗,观察组患儿在对照组治疗的基础上联合使用肺表面活性物质进行治疗,观察两组患儿的临床疗效。结果:治疗后两组患儿的肺动态顺应性(lung dynamic compliance,Cdyn)均有不同程度的升高,其中观察组自用药2 h后的各时间点均高于基础值(P<0.05);对照组在治疗12 h后的各时间点均高于基础值(P<0.05),氧合指数(oxygenation index,OI)出现不同程度的降低,其中观察组自用药2 h后的各时间点均低于基础值(P<0.05);对照组在治疗12 h后的各时间点均低于基础值(P<0.05)。观察组患儿的Cdyn从治疗后2 h开始在各时间点均高于对照组(P<0.05),OI低于对照组(P<0.05)。结论:无创辅助通气联合肺表面活性物质治疗新生儿肺损伤可提高患儿的临床疗效。

Objective：To investigate the clinical effect of noninvasive ventilation combined with pulmonary surfactant in the treatment of neo- natal acute lung injury. Methods： 120 infants with acute lung injury hospitalized from January 2014 to December 2016 were randomly divided into the observation group and the control group （ n = 60）. The control group was treated with noninvasive ventilation while the observation group was treated with pulmonary surfactant on the basis of the treatment used in the control group, the clinical efficacy of the two groups compared. Results： After treatment, the levels of lung dynamic compliance （Cdyn） in the two groups were increased with different degrees, and oxygenation index （OI） decreased with different digrees; 2h after medication , there was significant difference in the observation group （ P 〈0.05 ） ; 12h after medi- cation , there was significant difference in the control group （ P 〈 0.05 ）. 2h after treatment, Cdyn in the observation group at each time point was higher than that of the control group while OI in the observation group was lower than that in the control group, the difference being significant （ P 〈 0.05 ）. Conclusion ： The use of noninvasive ventilation combined with pulmonary surfactant in the treatment of neonatal lung injury can signifi- cantly improve the clinical efficacy.