从中医“痰湿”诸证看TNF-α在多囊卵巢综合征证治中的作用

Role of TNF-α in Pathogenesis of Polycystic Ovary Syndrome from Perspective of Phlegm-Dampness Pattern

多囊卵巢综合征(PCOS)是最常见的妇科疾病,其病因至今仍尚未彻底解读,中医认为痰湿是PCOS的重要病因。诸多研究表明,肿瘤坏死因子-α(TNF-α)水平和具有痰湿证候的疾病,特别是PCOS具有直接的正相关;TNF-α抑制剂可以类似于化痰燥湿中药有效地治疗这些病证;同时,TNF-α抑制剂又有类似于化痰祛湿中药作用于人体的"伤阴"副作用。因此,体内TNF-α水平的升高可能是PCOS等疾病"痰湿证"的物质基础。故而,笔者期待尝试研究TNF-α抑制剂用于PCOS的治疗,这将为PCOS更进一步的发病机制研究和临床治疗开拓崭新的思路和方法。

Polycystic ovary syndrome（ PCOS） is one of the most common gynecologic diseases. Its etiology is still not completely understand. Traditional Chinese medicine thinks phlegm-dampness is an important cause of PCOS. Many studies have shown that the tumor necrosis factor alpha（ TNF alpha） has positive correlation with the phlegm-dampness syndrome,especially in PCOS. The effective TNF alpha inhibitors are similar to treatment of the dampness and phlegm prescriptions in these diseases. At the same time,the TNF alpha inhibitors have side effects similar to Yin deficiency due to resolving dampness and phlegm medicine. Therefore,the increase of TNF alpha level in the body might be the material basis for the phlegm-dampness syndromes in PCOS disease. Therefore,we are looking forward to the research of TNF alpha inhibitors on the treatment of PCOS,which would be further research for the pathogenesis and clinical treatment of PCOS.