中西医结合治疗多发性斑秃疗效及远期复发情况观察

Integrative Treatment of multiple Alopecia Areata and Long-term Follow-Up Recurrence

目的:观察中西医结合治疗多发性斑秃疗效及远期复发情况。方法:将就诊于医院脱发专病门诊的80例多发性斑秃患者,随机分为中西医结合组和西药组,每组各40例。所有患者常规使用基础性药物治疗:外用5%米诺地尔酊和0.05%丙酸氟替卡松乳膏。西药组予复方甘草酸苷片口服,中西医结合组口服止脱生发汤,连续治疗3个月后,判定临床疗效并进行统计学分析。结果:观察中西医结合组和西药组治疗后的临床疗效,中西医结合组的显效率为75.0%,总有效率为95.0%,西药组的显效率为27.5%,总有效率为77.5%,差异有统计学意义(P<0.05)。中西医结合组进展期和静止期的显效率分别为76.2%,73.7%,西药组进展期和静止期的显效率分别为18.2%,38.9%,进行统计学比较,差异均有统计学意义(P<0.05)。对两组中的痊愈患者随访1年,中西医结合组和西药组的复发率分别为17.6%和80%,两组比较,有统计学差异(P<0.05)。结论:所采用中西医结合治疗多发性斑秃的方法较单纯使用西药的方法可以提高临床疗效,并可以降低远期复发率。在连续治疗的3个月期间,中西医结合组的患者出现药物相关的不良反应少且轻微。本研究采用的中西医结合治疗多发性斑秃的方法值得临床推广使用。

Objective： To observe clinical effects of the integrative medicine on multiple alopecia areata and long-term recuurence rate in patients. Methods： A total of 80 patients with multiple alopecia areata from hair loss special disease clinic were randomly divided into integrated traditional Chinese and western medicine group and western medicine group,40 patients in each group. All patients were treated with general treatment,including topical 5% minoxidil tincture and topical 0. 05% fluticasone propionate cream. The western medicine group was given compound glycyrrhizin tablets orally and the integrative treatment group was treated with Zhituo Shengfa Decoction. Clinical efficacy and statistics analysis were performed after continuous treatment for 3 months. Results： To compare the clinical efficacy of two groups after treatment,in the integrative treatment group,the explicitly effective rate was 75% and the total effective rate was 95%.In the western medicine group,that was 27. 5% and 77. 5% respectively. Compared to the two groups,there was statistically significant difference（ P〈0. 05）. Explicitly effective rate in the integrative treatment patients with advanced stage and resting stage group was 76. 2% and 73. 7% respectively. The explicitly effective rate in the western medicine group in advanced stage and resting stage was 18. 2% and 38. 9% respectively. There was significant difference（ P〈0. 05）.Cured patients of two groups were followed up for 1 year. The recurrence rate of the integrative treatment group and western medicine group was 17. 6% and 80%,respectively. There was statistically significant difference（ P〈0. 05）. Conclusion： The integrated traditional Chinese and western medicine treatment of multiple alopecia areata was more effective than single western medicine,but also can reduce the long-term recurrence rate. During the 3 months of continuous treatment,patients in the integrative medicine group had few and mild adverse drug reactions. It is worthy of clinical use for treatment of multiple alopecia areata combined with traditional Chinese medicine and western medicine.