天然药物化学史话:雷帕霉素

Historical story on natural medicinal chemistry: Rapamycin

天然产物化学研究在药物研发中起着非常重要的作用。微生物是新药的主要来源之一,雷帕霉素就是一种从来自复活节岛土壤微生物中得到的化合物,它的发现引领了一系列免疫与抗癌药物的问世。科学家对雷帕霉素作用靶点的研究已取得了"诺贝尔奖级别"的成果。对雷帕霉素的研发历程进行回顾,期望能够为今后相关研究提供思路与启示。

The study on natural product chemistry plays an important role in drug development and microbe is one of the main sources of new drugs. Rapamycin is isolated from the bacterium ensconced in a sample of Easter Island＇s soil, the compound has led to several approved immunosuppressant and anticancer drugs. The researchers studying on the target of raparnycin have got the ＂Nobel-class＂ achievements. In this paper, the discovery and study on rapamycin is summarized to provide the references for future related research.