抑郁症患者伦敦塔任务下执行功能与抑郁的关系

Relationship between executive function and depressive symptoms during the tower of London test in patients with major depressive disorder

目的探索抑郁症患者伦敦塔任务下执行功能与抑郁之间的关系。方法2016年3～8月，对30名抑郁症患者和在性别、年龄、受教育年限与抑郁症组相匹配的30名健康对照进行汉密尔顿抑郁量表（24项）、汉密尔顿焦虑量表、贝克抑郁自评量表及伦敦塔任务（tower of London test，TOL）测试。结果（1）抑郁症组TOL测试的正确答题数、答题总数[分别为（9．1±5．1）个，（12．1±5．3）个]，低于正常对照组[分别为（13．8±5．0）个，（17．3±3．9）个]，差异有统计学意义（P〈0．01），TOL测试的平均答题时间[（10．4±2．8）s]长于正常对照组[（8．5±2．2）s]，差异有统计学意义（P〈0．05）；（2）相关分析：HAMD、BDI、HAMA评分与TOL答题总数之间呈负相关（r=-0．403，-0．544，-0．495，均P〈0．05）。结论在TOL测试下，抑郁症患者存在执行功能受损，且抑郁、焦虑症状的严重程度与执行功能之间存在负相关。

Objective To investigate the relationship between executive function and depressive symptoms in patients with major depressive disorder（MDD） under the Tower of London Test （TOL）. Methods Thirty depression patients and thirty age-, gender-, education-matched normal controls participated in the study. All subjects received the Tower of London Test. The severity of depressive and anxiety symptoms were assessed by Hamilton Rating Scale for Depression （HAMD）, Hamilton Anxiety Rating Scale （HAMA） and Beck Depression Rating Scale （BDI）. Results （ 1 ） The numbers of correct response and total response of the TOL in YIDD（9.1±5.1,12.1±5.3） were significantly lower than those of the control group（ 13.8±5.0, 17.3±3.9） （P〈0.05）.The response time of the TOL test in patients with MDD（（10.4±2.8） s） was significantly longer than that of the control group（ （8.5 ± 2.2 ）s ） （P〈 0.05 ）. （2）The scores of HAMD , BDI and HAMA were negatively correlated with numbers of total response（ r=-0.403,-0.544,-0.495, ） in patients with MDD （all P〈0.05 ）. Conclusion The executive function of patients with MDD is impaired and negatively correlated with depressive and anxiety symptoms under the Tower of London Test.