神经元特异性烯醇化酶及S100β蛋白在颅内感染及脑组织损伤评估中的临床意义

Clinical Significance of Neuron Specific Enolase and S100 Beta Protein in Intracranial Infection and Brain Injury

目的探讨脑脊液中神经元特异性烯醇化酶(NSE)、S100β蛋白水平在颅内感染及脑组织损伤评估中的临床意义。方法选取我院2014年5月至2016年5月收治的颅内感染患者40例作为感染组,另选取同期来我院进行体检的40名健康人员为对照组,应用罗氏COBAS-601全自动电化学发光仪及其配套试剂检测两组人员的脑脊液NSE、S100β蛋白水平,然后对其进行统计分析。结果感染组中病毒性感染患者的脑脊液NSE、S100β蛋白水平均显著高于化脓性、结核性感染患者,差异有统计学意义(P<0.05),但化脓性、结核性感染患者的脑脊液NSE、S100β蛋白水平差异无统计学意义(P>0.05);感染急性期昏迷患者的脑脊液NSE、S100β蛋白水平均显著高于未昏迷患者,差异有统计学意义(P<0.05)。化脓性、结核性、病毒性感染患者及感染急性期昏迷、未昏迷患者的脑脊液NSE、S100β蛋白水平均高于对照组,差异有统计学意义(P<0.05)。结论脑脊液中NSE、S100β蛋白水平能够将有效的参考依据提供给临床对颅内感染及脑组织损伤的评估。

Objective To investigate the clinical significance of neuron specific enolase（ NSE） and S100 beta protein lev-els in cerebrospinal fluid（ CSF） in the evaluation of intracranial infection and brain injury. Methods 40 patients with intracranial infection from May 2014 to May 2016 treated in our hospital were included as infection group,and 40 healthy persons were selected as the control group during the same period,the NSE and S100 beta protein levels of the two groups were detected by Roche CO-BAS-601 automatic electrochemiluminescence instrument and its matching reagent,then it carries on the statistical analysis. Re-sults NSE and S100 beta protein levels in cerebrospinal fluid in the infected group were significantly higher than those in the pa-tients with purulent,or tuberculous infection,the difference was statistically significant（P〈0. 05）. However,there was no signifi-cant difference in the levels of NSE and S100 beta protein in cerebrospinal fluid of patients with purulent and tuberculous infection （P〉0. 05）. NSE,S100 beta protein levels in Cerebrospinal fluid in patients with acute coma were significantly higher than those in non-coma patients,the difference was statistically significant（P〈0. 05）. The cerebrospinal fluid NSE,S100 beta protein levels in patients with purulent,tuberculous,viral infection and patients with or without acute coma,were higher than those in the control group,the difference was statistically significant（P〈0. 05）. Conclusion Cerebrospinal fluid NSE,S100 beta protein levels can provide an effective reference to the clinical evaluation of intracranial infection and brain tissue damage.