青蒿素代谢调控研究进展

Research progress on metabolic regulation of artemisinin

青蒿素是治疗疟疾的特效药并被广泛使用。黄花蒿中青蒿素的量很低,远不能满足需求,开展青蒿的代谢调控研究是提高青蒿素产量的有效手段。总结了影响青蒿素产量的多种因素,包括青蒿素生物合成及支路途径关键酶基因、转录因子、植物激素、逆境、诱导因子和腺毛等。通过概述各因素在青蒿素代谢调控中的研究进展,归纳出基于青蒿素生物合成途径的常规次生代谢调控策略和基于腺毛的新型代谢调控策略,丰富了青蒿素代谢调控的路径,为培育优质高产转基因青蒿品系和改良青蒿种质遗传提供新思路。

Artemisinin is widely used for the treatment of malaria. Artemisia annua fielded low artemisinin, which was far behind the requirements. The study on the metabolic regulation of A. annua is an effective way to improve the yield of artemisinin. Metabolic regulation of artemisinin is an effective approach to improve the yield of artemisinin. In this paper, the variety of factors that affect artemisinin content was summarized, including biosynthesis in artemisinin and its branch pathway of key enzyme genes, transcription factors, phytohormones, environmental stress, induction factors, trichomes, etc. By reviewing the research progress of these factors in metabolic regulation of artemisinin, new strategies in conventional secondary metabolic engineering were generalized based on artemisinin and its branch biosynthesis pathway and fresh metabolic engineering based on trichomes. These strategies enriched the pathway in metabolic regulation of artemisinin and put forward a new idea to cultivate transgenic strain of A. annua with good quality and high yield.