清热燥湿法联合瑞舒伐他汀对2型糖尿病患者血液生化指标及体质的影响

Effect of heat-clearing and dampness-expelling therapy combined with rosuvastatin on blood biochemical parameters and physical fitness in patients with type 2 diabetes mellitus

目的探究清热燥湿法联合瑞舒伐他汀对2型糖尿病(type 2 diabetes mellitus,T2DM)患者血液生化指标及体质的影响.方法选取宁波大学医学院在2015-03/2015-12接受治疗的患者86例T2DM患者,将患者按照随机数表的方式分成对照组和实验组各43例.对照组服用瑞舒伐他汀,实验组在对照组的基础上给予清热燥湿法治疗,治疗12 wk后观察两组患者的各项血液生化指标和体质指标以及不良反应.结果实验组治疗后空腹血糖下降的幅度较对照组明显(6.14 mmol/L±2.14 mmol/L vs 7.04mmol/L±2.15 mmol/L,P<0.05),差异具有统计学意义;实验组治疗后甘油三酯下降的幅度较对照组明显(1.43 mmol/L±0.16 mmol/L vs 1.74 mmol/L±0.23 mmol/L,P<0.05),差异具有统计学意义;实验组治疗后体脂百分比下降幅度较对照组明显(29.16±4.29 vs 34.24±4.52,P<0.05),差异具有统计学意义;两组患者治疗后均无明显过敏、恶心呕吐、腹泻、肌痛等不良反应现象.结论清热燥湿法联合瑞舒伐他汀能够降低T2DM患者各项血液生化指标,提高患者的体质健康水平,治疗效果显著.

AIM To evaluate the effect of heat-clearing and dampness-expelling therapy combined with rosuvastatin on biochemical indexes and physical fitness in patients with type 2 diabetes mellitus （T2DM）.METHODS Eighty-six type 2 diabetic patients treated at our hospital from March 2015 to December 2015 were selected and randomly divided into a control group and an experimental group, with 43 cases in each group. Patients in the control group were treated with heat-clearing and dampness-expelling therapy alone, and the experimental group was treated with heat- clearing and dampness-expelling therapy plus rosuvastatin. After 12 wk of treatment, blood biochemical indexes, physical indexes and adverse reactions of the two groups were compared.RESULTS After treatment, fasting blood glucose and triglyceride levels were significantly lower in the experimental group than in the control group （6.14 mmol/L ± 2.14 mmol/L vs 7.04 mmol/L ± 2.15 mmol/L, P 〈 0.05; 0.16 mmol/L ± 1.43 mmol/L vs 1.74 mmol/L ± 0.23 mmol/L, P 〈 0.05）; body fat percentage was significantly lower in the experimental group than in the control group （29.16 ± 4.29 vs 34.24 ± 4.52, P 〈 0.05）. Patients in both groups showed no obvious adverse reactions such as allergy, nausea, vomiting, diarrhea, and muscle pain.CONCLUSION Heat-clearing and dampness-expelling therapy combined with rosuvastatin can reduce blood biochemical parameters and improve physical fitness in patients with T2DM, with no obvious adverse reactions.