外耳道注入派瑞松软膏治疗真菌性外耳道炎疗效观察

Effect observation of the external auditory canal injection of pevisone paste in the treatment of otomycosis

目的探讨外耳道注入派瑞松软膏治疗真菌性外耳道炎临床疗效。方法选取我院2014年1月~2016年1月期间门诊诊治的126例真菌性外耳道炎患者,共194耳,随机分成三组,对照组45例患者,共66耳,采用3%硼酸酒精滴耳液治疗,实验组A 43例患者,共67耳采用外耳道注射派瑞松软膏治疗,实验组B 38例患者,共61耳采用自行外耳道涂抹派瑞松软膏治疗,三组患者各治疗2周,观察治疗结束时临床疗效以及不良反应和生活质量等进行对比。结果经过三组患者的临床治疗对比,实验组A患者痊愈63耳,显效2耳、有效1耳、无效1耳,其总有效率为98.51%,不良反应率13.43%,实验组B患者痊愈36耳,显效10耳、有效5耳、无效10耳,其总有效率为83.61%,不良反应率24.56%,对照组患者痊愈30耳,显效15耳、有效8耳、无效13耳,其总有效率为80.30%,不良反应率68.18%,治疗组疗效及不良反应率均优于对照组患者(P<0.05),实验组A效果及不良反应率优于实验组B(P<0.05),具有统计学意义。结论外耳道注射派瑞松软膏治疗真菌性外耳道炎,疗效显著,且不良反应小,值得推广应用。

Objective To investigate the clinical effect of the external auditory canal injection of pevisone past in the treatment of otomycosis. Methods From January 2014 to January2016, 126 cases of patients with 194 fungal otitis externa were randomly selected to be divided into three groups through the draw method. In the experimental group A, 43 patients（67 ears） with otomycosis used auditory canal pevisone paste injection, while in the experimental group B, 38 patients（61 ears） with otomycosis used pevisone by themselves. In the control group, there were 45 patients（66 ears） with otomycosis treated with 3% boric alcohol. After the treatment of 2 weeks, the clinical curative effect, adverse reaction and quality of life of the three groups of patients were compared at the end of treatment. Results After comparing the clinical treatment among the three groups of patients, in the experimental group A,63 ears were cured, 2 cases were markedly effective, 1 case was valid, 1 case was invalid, the patients＇ total effective rate were98.51%, the adverse drug reaction（ADR） rate were 13.43%; in the experimental group B, 36 ears were cured, 10 cases were markedly effective, 5 cases were valid, 10 cases were invalid, the patients＇ total effective rate were 83.61%, ADR rate were 24.56%; in the contol group, 30 ears were cured, 15 cases were markedly effective, 8 cases were valid, 13 cases were invalid, the patients＇ total effective rate were 80.30%, ADR rate were 68.18%. Both of the two experimental groups patients＇ total effective rate was better than the control group patients（P〈0.05）, the experimental group A patients＇ total effective rate was better than the experimental B group patients（P〈0.05） with statistical significance. And the ADR rate of the experimental A group patients was more less than the other two groups patients. Conclusion External auditory canal Pevisone paste injection treatment applied to the treatment of the fungal otitis externa, has obvious curative effect and less adverse reactions, is worthy of promotion.