小牛血清去蛋白注射液对急性重型颅脑损伤患者脑脊液内乳酸浓度的影响

Effect of deproteinized calf serum injection on lactic acid in cerebrospinal fluid of patients with acute severe brain injury

目的探讨小牛血清去蛋白注射液对急性重型颅脑损伤患者脑脊液内乳酸浓度的影响。方法同济大学附属第十人民医院神经外科于2014年1月至2016年1月收治的60例急性重型颅脑损伤患者随机分成小牛血清去蛋白注射液治疗组(32例)和对照组(28例),比较2组间脑脊液中的乳酸含量、脑脊液内乳酸和糖含量的比值和3个月后的预后情况。结果自治疗观察第3天开始,与对照组相比,小牛血清去蛋白注射液治疗组的脑脊液内乳酸含量出现明显下降;但2组间的脑脊液乳酸和脑脊液糖比值没有明显差异,差异无统计学意义(P>0.05)。3个月后的GOS评分上,小牛血清去蛋白注射液治疗组(3.86±1.10)高于对照组(3.39±0.58),差异有统计学意义(P<0.05)。结论小牛血清去蛋白注射液可以有效降低急性重型颅脑损伤患者脑脊液内乳酸浓度,改善脑组织有氧代谢,对改善预后有一定的作用。

Objective To investigate the effect of deproteinized calf serum injection on lactic acid in cerebrospinal fluid of patients with acute severe brain injury. Methods Sixty patients with severe brain injury in Department of Neurosurgery of Tenth Peoples Hospital of Tongji University,from January 2014 to January 2016,were randomly divided into the group with treatment of deproteinized calf serum injection and the control group. The lactic acid contents in cerebrospinal fluid,the ratio of cerebrospinal fluid lactic acid and sugar contents were compared between 2 groups. The patients ＇prognosis after 3 months was compared too. Results The lactic acid contents in cerebrospinal fluid of deproteinized calf serum injection group were less than the control one during the treatment period after3 d（P〈0.05）. There is no significant difference in the ratio of lactic acid and sugar in the cerebrospinal fluid between them（P〉0.05）. And after 3 months,the scores of GOS were 3.86 ±1.10 and 3.39±1.58（P〈0.05）,respectively,the prognosis of treatment group was better in the group with treatment of deproteinized calf serum injection. Conclusion The deproteinized calf serum injection can effectively reduce the lactate acid in cerebrospinal fluid of patients with acute severe brain injury,improve aerobic metabolism in brain tissue,and improve the prognosis possibly.