摘要
以钯为催化剂,炔酸为炔基化试剂,采用脱羧偶联的方法实现了吲哚的去芳构化炔基化反应.以中等到良好的收率,高非对映选择性地合成一系列2,3-位具有连续季碳和叔碳中心的双取代吲哚啉化合物.
A palladium-catalyzed indole dearomative arylalkynylation via decarboxylative coupling of alkynyl carboxylic acids and alkyl-palladium intermediates has been developed, which provides a reliable approach to a serious of structural di- versely 2,3-disubstituted indolines bearing vicinal tertiary and quaternary stereocenters in moderate to good yields and excel- lent diastereoselectivities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第3期691-697,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金基金(Nos.21372202
1522207)资助项目~~
关键词
均相催化
钯
吲哚
去芳构化
炔基化
homogenous catalysis
palladium
indole
dearomatization
alkynylation
