碱促进下碳二亚胺参与构建二氢喹唑啉及其衍生物

Base Promoted Annulation of Carbodiimides to Access of Quinazoline and Their Derivatives

发展了一种由含碳二亚胺结构的α,β-不饱和酮/酯和醇类化合物合成一系列具有潜在生理和药理活性的2-乙氧基-3-苯基-3,4-二氢喹唑啉杂环化合物的方法.反应条件温和、耗时短,且为无金属催化反应,反应收率最高可以达到99%.这为进一步构建喹唑啉这类含氮杂环化合物提供了一种有益策略.

An efficient methodology to access of quinazoline derivatives by the reaction of carbodiimides and alcohol under basic conditions has been developed. This paper provides an attractive strategy for construction of the quinazoline compounds and other heterocyclic compounds in a high reaction yield by using simple starting materials in mild reaction conditions and short reaction time.