伴有视网膜病变的2型糖尿病患者的静息态功能磁共振研究

Study of Resting-state Functional Magnetic Resonance Imaging of T2DR

目的研究了2型糖尿病(T2DM)、伴有视网膜病变的2型糖尿病(T2DR)患者双侧后扣带回、双侧海马、双侧楔前叶及双侧小脑后叶等为种子点与全脑其他脑区功能连接的改变及意义。方法分别作种子点脑区与其他脑区的功能连接图,利用双样本t检验方法比较脑功能连接的差异,并探讨与临床参数的相关性。结果 T2DM患者与正常对照者,T2DR患者与T2DM患者相比种子点脑区与某些脑区的功能连接强度发生了改变,并且与临床参数存在相关性。结论 T2DM、T2DR患者脑功能连接异常改变的脑区主要与情感、记忆认知、视觉控制等有关。

Objective To explore the changes and meaning of bilateral posterior cingulate cortex，hippocampus, precuneus, posterior cerebellum lobe to all the other parts of the whole brain for T2DM and T2DR patients. Methods The differences of functional connectivity strengthen expressed were calculated and analyzed between seed points to all the other parts of the whole brain after rs-fMRI scan by two sample t-test. Also The correlations of the functional connectivity with clinical parameters were discussed. Results The functional connectivity had changed between some seed points and other brain regions comparing T2DM to controls and T2DR to T2DM. The changed functional connectivity were also correlated with clinical parameters. Conclusion The changed brain regions of T2DM and T2DR were relevant to emotion, memory, cognitive and visual control.