利拉鲁肽对2型糖尿病患者血清炎症因子及脂联素的影响

Effects of Liraglutide on Serum Inflammatory Factors and Adiponectin in Patients with Type 2 Diabetes Mellitus

目的:探讨利拉鲁肽对2型糖尿病患者血清炎症因子及脂联素的影响。方法:2型糖尿病患者60例(2015年1月~2016年1月),另外选择同期健康体检者60例,比较两组各项检测指标。结果:观察组和对照组的BMI、SBP、DBP、TC、TG无明显差异,P>0.05;和对照组对比,观察组治疗前FPG、2hPG、HbA1c、IL-6、TNF-a、Hs-CRP、APN明显更高,P<0.05;和治疗前对比,观察组治疗后FPG、2hPG、HbA1c、IL-6、TNF-a、Hs-CRP、APN明显上升,P<0.05。结论:利拉鲁肽应用于2型糖尿病患者的治疗中,能够有效地降低血清炎症因子和脂联素水平,值得临床广泛应用以及推广。

Objective：To investigate the effect of liraglutide on serum inflammatory factors and adiponectin in patients with type 2 diabetes mellitus.Methods： 60 cases of type 2 diabetes mellitus （January 2015-January 2016） were selected, and concurrent health examination in another 60 cases, then compare the two groups of the test indicators.Results：There was no significant difference in BMI,SBP,DBP,TC and TG between the observation group and the control group （P〉0.05）.Compared with the control group,the levels of FPG,2hPG, HbA1c, IL-6, TNF-a, Hs-CRP, and APN of observation group were significantly higher （P 〈0.05）.The levels of FPG, 2hPG, HbAlc, IL-6, TNF-a, Hs-CRP and APN in the observation group were significantly higher than those before treatment （P〈0.05）.Conclusion： Lilapride can be used in the treatment of type 2 diabetes mellitus, which can effectively reduce the levels of serum inflammatory factors and adiponectin, and it is worthy of clinical application and popularization.