摘要
布比卡因误入血管后会引起严重的心脏毒性.布比卡因的心脏毒性不仅具有直接的心肌毒性作用,而且能够通过中枢神经系统引起间接的心肌毒性.最近报道称布比卡因过量或误入血管能够引起交感神经系统异常兴奋.同时,临床研究显示肾上腺素不能解救甚至会加重布比卡因的心脏中毒,但其机制仍需进一步证实.
Bupivacaine has become a widely used local anesthetic,but exhibits a strong tendency to cardiac toxicity when accidentally administered intravenously.Numerous animals studies aimed at elucidating the mechanism of bupivacaine＆#39;s cardiotoxicity focused on the direct inhibition of myocardial.However,recent studies have led to speculating that the cardiovascular toxicity of bupivacaine is mediated,at least in part,by drug actions within the central nervous system.It has been found that epinephrine,a β-adrenergic agonist,can not rescue or even exacerbate the cardiotoxicity of bupivacaine.Experiments are needed to explore further the underlying mechanism.
出处
《实用疼痛学杂志》
2016年第6期435-440,共6页
Pain Clinic Journal
基金
河北省科技厅科技惠民项目（编号：16277715D）
关键词
布比卡因
药物毒性
心肌
中枢神经系统
肾上腺素
Bupivacaine
Drug toxicity
Myocardium
Central nervous system
Epinephrine
