探讨脉冲振荡技术应用于慢性咳嗽患者支气管舒张试验中的临床价值

Explore the clinical value of applying impulse oscillometry in bronchial dilation test for patients with chronic cough

目的探讨脉冲振荡技术(IOS)应用于慢性咳嗽患者支气管舒张试验中的临床价值。方法共纳入62例慢性咳嗽患者为研究对象,根据使用支气管舒张剂前的气道阻力水平分为气道阻力增高组(研究组)30例和气道阻力正常组(对照组)32例。测定两组患者肺通气功能、气道阻力,并完善支气管舒张试验,进而比较使用支气管舒张剂前后肺通气功能及气道阻力的各项指标变化情况和支气管舒张试验阳性率。结果支气管舒张剂使用后,两组患者FEV1%、PEF%、MEF75%、MEF50%、MEF25%和MMEF%各项肺通气功能指标均显著升高,差异有统计学意义(P<0.05)。气道阻力各项指标也均有明显改善(P<0.05);同时,研究组支气管舒张试验阳性率83.3%,显著高于对照组25.0%,差异有统计学意义(P<0.05)。结论 IOS用于慢性咳嗽患者的支气管舒张试验中,可更好地筛选适合做支气管舒张试验的患者,提高支气管舒张试验的阳性率,为慢性咳嗽患者的诊治提供依据。

Objective To discuss the clinical value of Impulse Oscillometry （IOS） used in bronchial dilation test for chronic cough patients.Methods 62 patients with chronic cough were chose as research subjects, According to the difference of airway resistance before use the bronchodilators, 62 patients with chronic cough were divided into two groups： the treatment group with high airway resistance （30） and the control group with normal airway resistance （32）. Tested lung ventilation function, airway resistance and given bronchial dilation test. Then compared the indexes change of lung ventilation function and airway resistance and the positive rate of the bronchial dilation test. Results The ventilation function （FEVI%, PEF%, MEF75%, MEF50%, MEF25% and MMEF% ） and airway resistance were significantly improved after the using of the bronchodilators than before （P〈0.05）. The positive rate of the bronchial dilation test of the treatment group （83.3%） was higher than the control group （25.0%, P〈0.05）. Conclusions The using of the IOS in the bronchial dilation test can help filtrate patients who suit for the bronchial dilation test. Also it can improve the positive rate of the bronchial dilation test and the diagnosis rate of CVA.