非甾体类抗炎滴眼液在白内障术前应用的疗效观察

Therapeutic efficacy of utilization of nonsteroidal pranoprofen eye drops in treating cataract by phacoemulsification

目的术前应用非甾体类抗炎滴眼液(普拉洛芬)点眼对白内障超声乳化患者术后观察指标的疗效分析。方法选取本院2015年6—12月期间行白内障超声乳化联合人工晶体植入术患者56例(56只眼),随机分为两组:观察组28例,术前3天联合应用左氧氟沙星滴眼液及普拉洛芬滴眼液,每日各4次点眼;对照组28例,术前单独给予左氧氟沙星滴眼液点眼,每日四次,两组用药前及术后1天均进行结膜囊细菌培养。观察术后1天眼压、炎症症状评分、炎症体征评分和结膜囊细菌培养结果。结果眼压值两组对比P>0.05,无统计学差异。术后1天炎症症状评分及炎症体征评分两组相比P<0.05,差异有统计学意义;两组结膜囊细菌培养结果对比P>0.05,无统计学差异。结论白内障超声乳化联合人工晶体植入术术前结膜囊抗生素滴眼液联合非甾体类抗炎滴眼液用药可以有效降低患者术后眼部炎症反应。

Objective Analysis on the effect of using nonsteroidal pranoprofen eye drops before eye operations on the therapeutic efficacy after phacoemulsification.Methods 56 patients （56 eyes ） who underwent phacoemulsification during June and December 2015 were selected and randomly divided into two groups. Patients in treatment group （n= 28） using Levofloxacin and Pranoprofen eye drops since three days before surgery, four times a day. Control group （n=28） was treated with Levofloxacin eye drops only, also four times a day. one day before and after eye drop treatment, conjunctiva sac bacteria culture was performed for the patients of both groups. One day after the phacoemulsification procedure, eye pressure was measured and inflammatory responses were evaluated and inflammation severity and subjective symptoms were scored, and results of conjunctival sac bacteria culture were also analyzed. Results The eye pressure showed no statistical significance between two groups, however, the inflammation severity and subjective symptom score showed significance P〈0.05. Combination of Levofloxacin and pranoprofen eye drops significantly reduced inflammatory responses. There was no statistical difference in the eonjunctival sac bacteria culture resuhs. Conclusions Utilization of nonsteroidal Pranoprofen and Levofloxacin antibiotic eye drops in treating cataract by phacoemulsification can effectively decrease the topical inflammation in the eyes that undergo operation.