学龄前哮喘患儿血清维生素D水平与哮喘的相关性研究

Correlation of Serum Vitamin D Level with the Incidence of Asthma in Preschool Children

目的:探讨学龄前哮喘患儿血清25-(OH)-Vit D水平与哮喘的相关性。方法:53名学龄前哮喘患儿和30名健康学龄前儿童纳入本研究,测定血清维生素D水平和Fe NO,并对两组儿童的体质量、既往患过敏性鼻炎、湿疹情况,吸烟暴露情况,家族史,宠物接触情况及哮喘预测指数进行统计分析。结果:哮喘患儿与健康儿童相比,血清维生素D水平明显减低,Fe NO明显升高,同时有明显增高的过敏性疾病史、吸烟暴露、父母哮喘家族史,在患儿组中哮喘预测指数阳性较阴性者有更低的血清25-(OH)-Vit D水平。结论:哮喘患儿较正常儿童血清维生素D明显减少,补充维生素D可能有助于哮喘患儿的治疗。

Objective To investigate the relationship between serum vitamin D level and the incidence of asthma in preschool children. Methods The study included 53 preschool children with asthma and 30 healthy preschool children. The serum levels of vitamin D was determined and Fe NO test was performed,and the children＇s weight,past suffering from allergic rhinitis,eczema,smoking exposure,family history,pets and the asthma predictive index of two groups were all statistically analyzed. Results Compared with healthy children,the serum vitamin D levels of children with asthma were significantly decreased,but Fe NO were significantly increased,the ratio of allergic diseases history,smoking exposure,family history of asthma were obviously higher in asthma children. In the children with asthma,the asthma predictive index positive ones had lower serum 25-（ OH）-Vit D level than the negative ones. Conclusion The serum levels of vitamin D was significantly decreased in children with asthma than in normal children,the supplement of vitamin D may be helpful for their treatment.