辽宁省呼吸道综合征病毒感染特征研究

Characteristics of respiratory virus infection in Liaoning province

目的了解辽宁省呼吸道感染状况,探讨辽宁省呼吸道病毒感染患者特征。方法收集辽宁省内2012-2014年11家监测哨点医院纳入的呼吸道综合征的患者信息,对采集的样本开展流感病毒、副流感病毒、腺病毒、呼吸道合胞病毒、人冠状病毒、人鼻病毒、人偏肺病毒和人博卡病毒检测。应用SPSS20.0统计软件,计数资料采用χ^2=验,计量资料采用t检验,P〈0.05为差异有统计学意义。结果共纳入患者692例,呼吸道病毒检测阳性143例,总阳性检出率20.66%,未检测到人博卡病毒。门急诊患者64例（44.76%）,住院患者79例（55.24%）,差异有统计学意义（χ^2=7.59,P=0.00）。单一病原阳性140例,混合感染3例。发热和咳嗽为最主要的临床症状。病毒阳性患者中头痛（χ^2=16.01,P=0.01）;腹痛（χ^2=13.14,P=0.04）和肺部听诊异常（χ^2=12.89,P=0.02）差异均有统计学意义。白细胞水平与是否病毒感染间差异无统计学意义（χ^2=0.24,P=0.89）。结论辽宁省呼吸道综合征患者临床表现发热为第一位,咳嗽为第二位。流感病毒是辽宁省呼吸道综合征检出的优势病原。

Objective To understand the etiological and clinical characteristics of respiratory virus infection in Liaoning province. Methods Clinical data and respiratory samples of patients with respiratory syndrome were collected in 11 hospitals from 2012 to 2014. Eight types of viruses including influenza virus, parainfluenza virus, adenovirus, respiratory virus, human coronavirus, human rhinovirus, human metapneumovirus and human bocavirus were detected by RT-PCR. Chi-square test and student t test were used for data statistical analysis. Results 692 cases were enrolled into the study and samples from 143 cases were positive for respiratory viruses with the overall positive rate of 20. 66 %. No sample was positive for human bocavirus, The difference of number of inpatient and outpatient was statistically significant （x^2= 7.59, P=0.00） . 140 cases were positive for single pathogen, and 3 cases were mixed infection. The most common clinical symptoms of cases were fever and cough. The differences of headache （x^2 = 16.01, P = 0.01 ）, abdominal pain （x^2 = 13.14, P = 0.04） and abnormal lung auscultation （x^2= 12.89, P = 0.02） of patients with positive virus were statistically significant. There was no difference between WBC count and virus infection （x^2=0.24, P=0. 89） . Conclusions Fever and cough are the most common clinical manifestations of patients with respiratory syndrome in Liaoning province, and influenza virus is a predominant pathogen.