血清总IgE、诱导痰细胞学分类检测对支气管哮喘的病情评估价值

Significance of detecting of serum total immunoglobulin E and induced sputum cytological classification in bronchial asthma

目的观察血清总IgE、诱导痰细胞学分类在支气管哮喘治疗前后的变化,探讨其应用价值。方法患者入院次日及第8天超声雾化高渗盐水诱导咳痰,痰液处理后进行炎性细胞分类,依据初次诱导痰细胞学分类结果对患者分组,并抽血测定各组血清总IgE浓度。结果嗜酸性粒细胞性哮喘组与混合细胞性哮喘组血清总IgE浓度治疗后明显下降;各组诱导痰细胞学构成治疗前后均有明显变化。结论血清总IgE、诱导痰细胞学分类检测是评价哮喘病情及指导治疗的简单有效的方法。

Objective To observe the changes of serum total IgE,induced sputum cytology classification in bronchial asthma before and after treatment,discuss their application value. Methods Sputum was induced by ultrasonic atomization hypertonic saline in the second day and the eighth day after admission. The patients were grouped according to the first induced sputum cytological classification results,and the serum total IgE concentrations were detected by chemiluminescence method. Results Serum total IgE concentrations significantly decreased after treatment in eosinophilic asthma group and mixed granulocytic asthma group. Induced sputum cytological classifications were significantly changed in all groups. Conclusion Detecting serum total IgE and induced sputum cytological classification were simple and effective tools for assessment and treatment in asthma.