不同抗结核药物与氧氟沙星及环丝氨酸对胸椎结核患者的临床疗效比较

Comparison of Clinical Efficacies Using Different Anti-TB Drugs with Ofloxacin and Cycloserine in Patients with Thoracic Spinal Tuberculosis

目的:比较不同抗结核药物与氧氟沙星及环丝氨酸对胸椎结核患者的临床疗效。方法:采用回顾性分析法分析2011年9月—2015年5月期间经抗结核药物治疗后施行手术的多节段胸椎结核患者37例,将其分为A组14例、B组17例和C组6例;术前分别给予A组"HREZ"抗结核治疗,B组HRE/Z与氧氟沙星治疗,C组HRE/Z与环丝氨酸治疗;药物治疗后再行手术治疗,比较各组患者手术前后药物治疗时间、住院时间和红细胞沉降率(ESR)、脊柱侧弯的角度(Cobb's)及肌力等指标的变化情况。结果:3组患者手术后ESR均低于治疗前(P<0.05),A组和B组患者手术后Cobb's均小于手术前(P<0.05)。结论:采用HREZ与氧氟沙星及环丝氨酸治疗胸椎结核患者疗效较为显著。

Objective： To compare the clinical efficacies using different anti-tuberculosis（anti-TB） drugs with ofloxacin and cycloserine in patients with thoracic spinal tuberculosis. Methods： Thirty-seven thoracic spinal tuberculosis patients who underwent anti-TB therapy from September 2011 to May 2015 were retrospectively analyzed. The patients were divided into group A（14 cases）,group B（17 cases） and group C（6 cases）. Patients before surgery in group A were treated with HREZ,group B with HRE/Z and ofloxacin,group C with HRE/Z and cycloserine. The surgery was conducted after drug therapy,and comparison was conducted between groups in patients with preoperative medication time,length of hospital stay and blood sedimentation,Cobb＇s angle and strength changes of the indicators. Results： The erythrocyte sedimentation rate（ESR） of the three groups was lower than that before treatment（P〈0.05）. The angle of scoliosis（Cobb＇s angle） in group A and group B was less than that before operation（P〈0.05）. Conclusion： Clinical efficacy of anti-TB treatment of HREZ with ofloxacin and cycloserine in patients with thoracic tuberculos is significant.