急性冠脉综合征患者发病早期外周血sFlt-1水平及临床意义

Levels and the clinical significance of sFlt-1 levels in the early acute coronary syndrome patients

目的:探讨急性冠脉综合征(acute coronary syndrome,ACS)患者发病早期外周血可溶性血管内皮生长因子受体1(soluble fms-like tyrosine kinase receptor 1,sFlt-1)水平的变化及临床意义。方法:选取150例在胸痛、胸闷6 h内就诊的患者,根据最终临床诊断其中102例ACS患者入选ACS组,48例排除ACS的患者入选对照组;比较两组患者入院即刻外周血sFlt-1水平,并绘制受试者工作特征(ROC)曲线,计算曲线下面积,分析血浆sFlt-1水平对ACS的诊断效能。结果:ACS患者发病早期的血浆sFlt-1水平(361.7±288.0)pg/m L显著高于对照组[(126.2±49.6)pg/m L,P<0.01];入院即刻采用sFlt-1单点值诊断ACS的ROC曲线下面积为0.852。结论:血浆sFlt-1在ACS发生的早期显著升高,早期检测sFlt-1有助于ACS患者的早期诊治。

Objective： To explore the clinical values of the peripheral soluble fms-like tyrosine kinase receptor 1 （sFlt-1） levels in early acute coronary syndrome（ACS） patients. Methods： A total of 150 patients who were admitted to hospital in six hours after chest pain occurred were recruited and divided into control group （n =48） or acute coronary syndrome group（ ACS, n = 102）, plasma sFh-1 were detected and compared between the two groups. Receiver operating characteristic （ROC） curve and area under curve （AUC） were analysed with SPSS 20.0 statistical software. Results： The levels of plasma sFlt-1 in ACS group were significantly higher compared with that of the control group [ （ 361. 7 ± 288.0 ） pg/mL vs （ 126.2± 49.6） pg/mL,P 〈 0.01] For the diagnosis of ACS, the AUC of sFlt-1 was 0. 852. Conclusion ： Plasma sFh-1 was significantly elevated in the early ACS patients, and it could be one of the earliest sensitive indicators in the diagnosis and risk estimation of ACS.