摘要
椎间盘退变被认为是腰背痛的主要原因,细胞死亡导致椎间盘细胞减少,细胞间基质代谢平衡被打破,基质降解增加,主导了椎间盘退变的过程。椎间盘退变中细胞死亡成为了研究焦点。本文通过分析总结椎间盘退变的相关文献,就椎间盘退变的诱导因素,椎间盘退变中细胞凋亡信号的转导进行综述。
Degeneration of inter-vertebral disc(IVD)is thought to be the leading cause of low back pain.cell death has been known to contribute to the degradation of ECM and plays an critical role in the process of IVD degeneration.Thus,the research on cell death in IVD degeneration has become a new focus.By analyzing the available literature related to cell death in IVD,we reviewed the inducing factors of IVD degeneration,apoptotic signal transduction pathways in IVD cell death for IVD degeneration.
出处
《内蒙古医学杂志》
2016年第12期1459-1463,1530,共6页
Inner Mongolia Medical Journal
关键词
椎间盘退变
细胞死亡
细胞间基质
信号转导
degeneration of inter-vertebral disc
cell death
extracellular matrix
signal transduction