抗耐甲氧西林金黄色葡萄球菌药物的研究进展

Research Progress in Study of Anti-MRSA Medicine

近年有多种逆转MRSA耐药的有潜力的抗菌药入市或进入后期临床研究阶段,其耐药机制各不相同。中药有效成分逆转MRSA耐药的研究也在逐年增加,证实多种中药有效成分单独应用可抑制耐药菌的生长,且可以通过组方的形式联合多种抗菌药物使用,具备不同耐药机制,产生协同作用,有效阻止细菌短期内耐药机制的发挥,降低耐药菌的进化。作者通过文献分析对报道的新型抗MRSA药物和中药有效成分进行综述归纳,探讨近年在研的新型抗菌药及中药对抗MRSA的效果及逆转耐药的机制。

In recent years,several kinds of pre-clinical and clinical molecule medicine were organized into categories with different regulating mechanisms and therapeutic effects on methicillin resistant Staphylococcus aureus（MRSA）. And the number of studies on active constituent in Chinses material medica is growing,and indicated that large amount of Chinese material medica inhibited growth of drug-resistance bacteria both in component and by using separately,to prevent resistant mechanism and the evolution of the bacteria. The purpose of this review was to discuss the mechanisms of molecules currently and Chinese material medica on antiMRSA properties via analysis.