桃红四物汤配合毫火针治疗原发性痛经临床疗效观察

Taohong Four Ingredients Decoction Combine with Filiform-fire Needle Therapy in Treating Primary Dysmenorrhea

目的：桃红四物汤配合毫火针治疗原发性痛经的近期和远期临床疗效。方法：将86例患者随机分组,桃红四物汤配合毫火针组（治疗组）43例和阿司匹林泡腾片治疗组（对照组）43例,2组研究分为治疗期（第1~3个月经周期）和随访期（第4~6个月经周期）,2个阶段。对照组采用阿司匹林泡腾片,0.5 g/次,3次/d,月经前5 d开始服用,直到月经来潮后1 d。治疗组采用：桃红四物汤内服,1剂/d,每月行经前5 d开始服药,服至月经来潮后1 d;毫火针每月行经前5 d开始第1次治疗,至月经来潮后1 d治疗1次。记录1~6个月经周期的痛经程度（VAS）;检测治疗前后血清PGE-2和PGF2α水平;检测治疗前后血液流变学。结果：2组第2个月经周期时点,VAS评分较第1个月经周期时点下降（P〈0.05）,2组第3、4个月经周期时点VAS评分均呈下降趋势;第5、6个月经周期时点2组VAS评分反弹,高于第4个月经周期时点（P〈0.05）,治疗组第1~6个月经周期时点VAS评分均低于对照组（P〈0.05）,治疗组组全血黏度、血浆黏度、全血还原黏度、纤维蛋白原和红细胞压积的改善均优于对照组（P〈0.05）,治疗组PGE-2高于对照组,PGF2α,PGF2α/PGE-2低于对照组（P〈0.05）结论：桃红四物汤配合毫火针治疗原发性痛经近期、远期疗效显著,其作用机制可能与改善血液循环,调节前列腺素有关。

Objective：To observe the curative effects of Taohong Four Ingredients Decoction combine with filiform -fire needle for primary dysmenorrheal .Methods：Total 86 patients with primary dysmenorrheal were randomized into 2 groups：Taohong Four In-gredients Decoction combine with filiform-fire needle group （the treatment group,n=43）,and effervescent aspirin （control group, n=43）.The treatments of the two groups were divided into treatment period （1-3 menstrual cycles） and follow-up period （4-6 menstrual cycles）.Patients in the control group received effervescent aspirin ,0.5 g/time,3 times/d,and the medicine was taken from 5 days before the first day of menstruation until 1 day after menstruation .Patients in the control group received Taohong Four Ingredients Decoction combine with filiform-fire needle （1.Took Taohong Four Ingredients Decoction from 5 days before the first day of menstruation until 1 day after menstruation .2.filiform-fire needle was performed at 5 days before menstruation began until after menstruation 1 days）.Degree of dysmenorrhea score （VAS） was recorded from 1-6 menstrual cycles before and after treat-ment,and levels of serous of PGF-2 and PGE-2a were detected as well as hemorheology .Results：The VAS score of the two groups decreased at the 2nd menstrual cycle compared with the 1 st menstrual cycle （P〈0.05=）.VAS scores of the two groups showed a decreasing trend at 3rd and 4th menstrual cycles;The 5th and 6th menstrual cycles VAS score rebound and became higher than the 4th menstrual cycle（P〈0.05=）.VAS scores of the treatment group were always lower than the control group during the 1 st to 6th menstrual cycles.Whole blood viscosity,plasma viscosity,whole blood reduced viscosity,fibrinogen and hematocrit of the treatment group were better than the control group （P〈0.05=）,PGE-2 in treatment group was higher than control group ,PGF2α, PGF2α/PGE-2 in treatment group lower than the control group （P〈0.05=） Conclusion：Taohong Four Ingredients Decoction com-bined with filiform-fire needle has significant short-term and long-term analgesic effect in treating primary dysmenorrhear .The mechanism may be related with improving the blood circulation and regulating prostaglandin .