补肾序贯结合活血化瘀方治疗子宫内膜异位症所致痛经的临床疗效及对CA125、PGF_(2α)、OT的影响

The clinical efficacy of dysmenorrhea caused by endometriosis and the influence on the sutems as CA125、PGF_(2α)、OT through the treatment of combination of Bushen Xuguan and activing blood circulation

目的:探讨补肾序贯结合活血化瘀中药对子宫内膜异位症所致痛经的临床疗效及对糖类抗原CA125、前列腺素(PGF_(2α))、催产素(OT)的影响。方法:将子宫内膜异位症痛经患者随机分成补肾序贯结合活血化瘀中药组(治疗组),中成药活血化瘀组(对照组),其中治疗组50例,对照组30例,观察治疗前后2组患者痛经改善情况,比较治疗前后2组患者血清CA125、PGF_(2α)、OT水平的变化。结果:治疗组治疗痛经总有效率为96%,对照组治疗痛经总有效率为86.6%,两者总有效率差异有统计学意义(P<0.05)。2组治疗后痛经程度评分及兼症改善评分均较治疗前差异有统计学意义(P<0.05),其中治疗组治疗后的兼症评分下降程度与对照组比较差异有统计学意义(P<0.05);治疗后2组患者血清CA125、PGF_(2α)、OT含量均较治疗前明显下降(P<0.05),比较治疗组的效果更加明显,其中对CA125及OT水平的影响与对照组比较差异有统计学意义(P<0.05)。结论:活血化瘀方治疗子宫内膜异位症痛经患者,可以明显改善患者的痛经和兼症症状,降调患者经期血清中CA125、PGF_(2α)、OT等水平,而与补肾序贯法结合使用则疗效更显著,推断中药活血化瘀方治疗内异症的作用机制可能与降调上述指标有关,而补肾序贯中药可能具有免疫调控机制,能够改善痛经患者内分泌环境,不利于异位内膜的黏附,侵袭,从其作用靶点即"源头"上遏制而显疗效。

Objective：To investigate the clinical efficacy of dysmenorrhea caused by endometriosis and the influence on the sutems as CA125、PGF2α、OT through the treatment of combination of Bushen Xuguan and activing blood circulation .Methods：The choice conforms to this topic diagnosis standard research object 80 examples stochastically divides in to the experimental group 50 exam-ples,the comparison group 30 examples.The experimental group uses Bushen Xuguan and activing blood circulation treatment of Tradition Chinese medicine .The comparison group uses activing blood circulation treatment of Chinese medicine .Improvement of dysmenorrhea and the serums as CA125、PGF2α、OT were tested pretherapy and after treatment .Results：The total efficiency（96%） of experimental group was higher than comparison group （86.6%）,the difference was significant （P〈0.05）.The two groups both can lower dysmenorrhea score and Jian Zheng score .Experimental group can effectively lower Jian Zheng sorce superior to compari-son group（P〈0.05）.The two groups both can lower the serums as CA 125、PGF2α、OT.Experimental group can effectively lower the serums as CA125、OT,superior to comparison group（P〈0.05）.Conclusion：Treatment of activing blood circulation can exten-uate dysmenorrhe and Jian Zheng in Endometriosis patients ,lower serums as CA125、PGF2α、OT.However the clinical efficacy of treatment of combination of Bushen Xuguan and activing blood circulation was better than treatment of activing blood circulation .So we can infer that mechanism of TMC was related with lowering the above-mentioned serums.At the same time,we can also infer that treatment of Bushen Xuguan can regulate immunity and endocrine .It is harmful to to adhesion and incursion of ectopic endom-etrial.Thereby it is a fundamental treatment .