加减消渴方联合二甲双胍对气滞血瘀型2型糖尿病相关临床指标的影响

Effect of Modified Xiaoke Decoction Combined with Metformin on Clinical Indicators of Patients with Type 2 Diabetes of Qi-Deficiency and Blood-Stasis Pattern

目的:探讨加减消渴方联合二甲双胍对气虚血瘀型2型糖尿病相关临床指标影响。方法:选择2型糖尿病患者100例,随机分为治疗组和对照组,治疗组给予二甲双胍,对照组给予加减消渴方和二甲双胍。对比治疗后血糖、脂质代谢、血液流变学指标、肌酐尿素氮、中医症状积分以及低血糖等指标变化。结果:2组治疗后血糖各指标均有所下降,将治疗前后血糖指标差值对比,治疗组各指标变化值均大于对照组(P<0.01);血脂、血液流变学、肌酐尿素氮指标方面,治疗后2组指标均有所下降,两者变化值比较,治疗组各指标均大于对照组(P<0.01);2组治疗后,中医症状积分和低血糖发生率均有所下降,将治疗前后指标对比,治疗组各指标均大于对照组(P<0.01)。结论:加减消渴方联合二甲双胍可明显改善2型糖尿病血糖、血脂、血液流变学指标等临床指标,有效的降低糖尿病并发症的发生,避免低血糖的发生率。

Objective：To explore the influence of clinical indicators by Modified Xiaoke Decoction combined with metformin in treatment of patients with type T2DM of qi-deficiency and blood-stasis pattern.Methods：A hundred cases with type 2 diabetes mellitus were randomly divided into the experimental group and the control group .Patients in the experimental group were given Modified Xiaoke Decoction and metformin , while those in the control group were treated with metformin .Blood sugar , blood fat , hemorrheology, Creatinine, Urea nitrogen, Chinese medicine symptom integral and hypoglycemia and other indicators before and after the treatment were compared .Results：Relevant indexes related to blood sugar of the two groups after treatment decreased . Changes in glycemic index value of the experimental group before and after the treatment were greater than that of the control group （P〈0.01）.Blood lipids, hemorrheology, creatinine, urea nitrogen decreased in the two groups after treatment and the decrease in the experiment group were greater than that of the control group （ P〈0.01） , traditional Chinese medicine symptom integral and the incidence of hypoglycemia of the two groups after treatment were decreased and the treatment group were more remarkable than the control group （P〈0.01）.Conclusion：Modified Xiaoke Decoction and metformin may significantly improve the clinical indi-cators such as T2DM blood sugar, blood lipid, effectively reduce diabetes complications and avoid the incidence of hypoglycemia .