正胆汤加减治疗稳定型心绞痛的临床研究

Clinical Study of Modified Zhengdan Decoction on the Treatment of Stable Angina

目的:探讨正胆汤加减对稳定型心绞痛的治疗效果。方法:选取2013年5月至2015年5月在我院治疗的70例冠心病稳定型心绞痛患者为研究对象,随机分为对照组和观察组,对照组给予常规西药治疗,观察组给予正胆汤加减治疗,治疗2周后,比较2组患者的治疗效果。结果:观察组治疗的有效率高于对照组;治疗后,2组患者发作次数和持续时间均较治疗前减少明显,组间比较显示治疗后观察组患者上述指标减少较对照组更为显著;治疗后,2组患者的TG、TC、LDL均较治疗前下降,但HDL较治疗前升高(P<0.05);且观察组上述指标的改善较对照组更为明显,差异具有统计学意义(P<0.05);治疗后2组患者的全血黏度低切、全血黏度高切、血浆黏度和红细胞压积均有所下降,但观察组下降幅度较对照组更为明显,差异有统计学意义(P<0.05)。结论:正胆汤加减能有效治疗冠心病心绞痛的临床症状,可能与其能够调节机体内血脂水平,进而改善血流动力学,降低血液黏滞度有关。

Objective：To discuss the effect of modified Zhengdan Decoction on treatment of stable angina .Methods：Seventy cases of stable angina patients hospitalized in the department of the researcher from May 2013 to May 2015were selected and randomly divided into control group and observation group .And the efficacy were compared after 2 weeks of treatment .The control group re-ceived general western medicine treatment ,the observation group modified Zhengdan Decoction .After 2 weeks of treatment ,the out-comes were compared.Results：The observation group had higher efficiency; After the treatment,patients had less frequency and duration of their attack than before ,andthe control group reduced more significantly; After treatment,TG,TC and LDL of the 2 groups decreased,but HDL increased（P〈0.05）;improvement of the indicators of the observation group were more obvious than those of the control group（P〈0.05）;after treatment,whole blood viscosity at low shear rate ,whole blood viscosity at high shear rate,plasma viscosity and hematocrit of both groups were decreased ,but the decline of the observation group was more obvious . Conclusion：Modified Zhengdan Decoction was effective on treating clinical symptoms of angina pectoris ,which may because that it regulated body lipid levels ,improved hemodynamics and reduced blood viscosity .